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World J Gastrointest Pathophysiol. Nov 15, 2014; 5(4): 514-522
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.514
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.514
Alterations of the gut microbiome and metabolome in alcoholic liver disease
Wei Zhong, Zhanxiang Zhou, Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, United States
Zhanxiang Zhou, Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27412, United States
Author contributions: Zhong W and Zhou Z worked together on the concept and outline of the article and the specific chapters were written by one of the authors in equal contribution.
Correspondence to: Zhanxiang Zhou, Professor, Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, 500 Laureate Way, Suite 4226, Kannapolis, NC 28081, United States. z_zhou@uncg.edu
Telephone: +1-704-2505800 Fax: +1-704-2505809
Received: May 24, 2014
Revised: July 1, 2014
Accepted: September 6, 2014
Published online: November 15, 2014
Processing time: 179 Days and 4.7 Hours
Revised: July 1, 2014
Accepted: September 6, 2014
Published online: November 15, 2014
Processing time: 179 Days and 4.7 Hours
Core Tip
Core tip: Excessive alcohol consumption causes alcoholic liver disease (ALD) with the mechanisms of pathogenesis largely unknown. Alterations of gut microbiota and metabolites are critical contributors to the development of ALD, which may lead to identification of therapeutic targets for ALD. This review summarizes recent findings of how alcohol-induced alterations of gut microbiota and metabolome, and discusses the mechanistic link between gastrointestinal dyshomeostasis and alcoholic liver injury.