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World J Gastrointest Pathophysiol. May 15, 2014; 5(2): 71-81
Published online May 15, 2014. doi: 10.4291/wjgp.v5.i2.71
Review of the diagnosis, classification and management of autoimmune pancreatitis
Derek A O’Reilly, Deep J Malde, Trish Duncan, Madhu Rao, Rafik Filobbos
Derek A O’Reilly, Deep J Malde, Trish Duncan, Department of Hepatobiliary and Pancreatic Surgery, North Manchester General Hospital, Manchester M8 5RB, United Kingdom
Derek A O’Reilly, Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester M8 5RB, United Kingdom
Madhu Rao, Department of Histopathology, North Manchester General Hospital, Manchester M8 5RB, United Kingdom
Rafik Filobbos, Department of Radiology, North Manchester General Hospital, Manchester M8 5RB, United Kingdom
Author contributions: O’Reilly DA, Malde DJ and Duncan T wrote the clinical sections; Rao M contributed to the pathological section; Filobbos R supplied the radiology section and images.
Correspondence to: Derek A O’Reilly, PhD, FRCS, Consultant HPB Surgeon and Honorary Senior Lecturer, Department of Hepatobiliary and Pancreatic Surgery, North Manchester General Hospital, Manchester M8 5RB,United Kingdom. doreilly@doctors.org.uk
Telephone: +44-161-7202277 Fax: +44-161-7202228
Received: December 31, 2013
Revised: March 27, 2014
Accepted: April 17, 2014
Published online: May 15, 2014
Processing time: 139 Days and 22.3 Hours
Core Tip

Core tip: Type 1 autoimmune pancreatitis (AIP) is the pancreatic manifestation of a multiorgan disease, named immunoglobulin G4 (IgG4)-related disease while type 2 AIP is a pancreas specific disorder not associated with IgG4. Making the correct diagnosis and differentiating the disease from pancreatic cancer is of the utmost importance; an agreed diagnostic pathway should be in place and a multidisciplinary approach taken with each patient.