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World J Gastrointest Pathophysiol. Nov 15, 2013; 4(4): 94-99
Published online Nov 15, 2013. doi: 10.4291/wjgp.v4.i4.94
Published online Nov 15, 2013. doi: 10.4291/wjgp.v4.i4.94
Intestinal barrier: Molecular pathways and modifiers
Min Kyung Jeon, Christina Klaus, Elke Kaemmerer, Nikolaus Gassler, Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
Author contributions: Jeon MK and Gassler N designed and wrote the article; Klaus C and Kaemmerer E critical reviewed the literature and made technical notes.
Correspondence to: Nikolaus Gassler, MA, Professor, Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. ngassler@ukaachen.de
Telephone: +49-241-8088897 Fax: +49-241-8082439
Received: June 24, 2013
Revised: August 28, 2013
Accepted: September 3, 2013
Published online: November 15, 2013
Processing time: 143 Days and 14.9 Hours
Revised: August 28, 2013
Accepted: September 3, 2013
Published online: November 15, 2013
Processing time: 143 Days and 14.9 Hours
Core Tip
Core tip: The pathogenesis of gastrointestinal diseases is associated with important molecular pathways such as Wnt, Notch, Hippo, transforming growth factor-β/bone morphogenetic protein or Hedgehog in controlling cell-fate determination. Here, we discuss how they contribute to homeostasis of intestinal epithelium.