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World J Gastrointest Pathophysiol. May 15, 2013; 4(2): 28-36
Published online May 15, 2013. doi: 10.4291/wjgp.v4.i2.28
Published online May 15, 2013. doi: 10.4291/wjgp.v4.i2.28
Duodenal epithelial transport in functional dyspepsia: Role of serotonin
Anne-Barbara Witte, Peter Thelin Schmidt, Department of Medicine Solna, Unit of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Karolinska Institute, SE-171 76 Stockholm, Sweden
Mauro D’Amato, Agneta Laurent, Department of Biosciences and Nutrition, Karolinska Institute Campus Huddinge, 141 86 Stockholm, Sweden
Steen Seier Poulsen, Niels Bindslev, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark
Svend Knuhtsen, Mark Berner Hansen, Department of Surgery K, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen NV, Denmark
Mark Berner Hansen, AstraZeneca Research and Development, 431 83 Mölndal, Sweden
Author contributions: The study was designed by Witte AB, Poulsen SS, Bindslev N, Hansen MB and Schmidt PT; Witte AB performed the research with the exception of PCR experiments and the histological staining process and analysed as well as summarized the data; Knuhtsen S performed the endoscopic examinations and assisted in characterizing patients and controls; Bindslev N and Hansen MB provided technical guidance and facilities for biopsy sampling and Ussing experiments; D’Amato M and Laurent A performed the expression studies; Poulsen SS contributed with histological evaluation and guidance in the field; Schmidt PT participated in the data analysis and held overall responsibility for ethical and economic aspects; all authors participated in the revision of the manuscript and approved the final version.
Supported by Grants from the Snedkermester Sophus Jacobsen and Wife Astrid Jacobsen’s Foundation, Else and Mogens Wedell-Wedellsborg Foundation, the Ihre Foundation, the Nanna Svartz Foundation as well as the Swedish Research Council; A Graduate Studentship Award from the Karolinska Faculty Foundation to Witte AB
Correspondence to: Dr. Anne-Barbara Witte, Department of Medicine Solna, Unit of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Karolinska Institute, Solna, SE-171 76 Stockholm, Sweden. anne-barbara.witte@ki.se
Telephone: +46-81-2000990 Fax: +46-85-1775768
Received: December 5, 2012
Revised: February 16, 2013
Accepted: April 13, 2013
Published online: May 15, 2013
Processing time: 184 Days and 9.6 Hours
Revised: February 16, 2013
Accepted: April 13, 2013
Published online: May 15, 2013
Processing time: 184 Days and 9.6 Hours
Core Tip
Core tip: The majority of patients with chronic symptoms from the gastro-duodenal region do not present signs of organic disease during routine examination, which commonly leads to the diagnosis of functional dyspepsia (FD). Our study strongly indicates the involvement of 5-hydroxytryptamine related duodenal mucosal mechanisms in FD pathogenesis. Future studies should further investigate alterations in up- and downstream effects related to HTR3E and HTR7 receptors.