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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Jun 1, 2023; 14(3): 46-70
Published online Jun 1, 2023. doi: 10.4291/wjgp.v14.i3.46
Published online Jun 1, 2023. doi: 10.4291/wjgp.v14.i3.46
Role of p53 suppression in the pathogenesis of hepatocellular carcinoma
Heena B Choudhary, Deepa S Mandlik, Department of Pharmacology, BVDU, Poona College of Pharmacy, Pune 411038, Maharashtra, India
Satish K Mandlik, Department of Pharmaceutics, BVDU, Poona College of Pharmacy, Pune 411038, Maharashtra, India
Author contributions: Choudhary HB, Mandlik SK and Mandlik DS were responsible for literature research and drafting of a manuscript; All authors have read and approved the manuscript.
Conflict-of-interest statement: No conflict of interest in among the authors.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deepa S Mandlik, PhD, Assistant Professor, Department of Pharma
Received: March 27, 2023
Peer-review started: March 27, 2023
First decision: April 8, 2023
Revised: May 19, 2023
Accepted: May 31, 2023
Article in press: May 31, 2023
Published online: June 1, 2023
Processing time: 65 Days and 23.9 Hours
Peer-review started: March 27, 2023
First decision: April 8, 2023
Revised: May 19, 2023
Accepted: May 31, 2023
Article in press: May 31, 2023
Published online: June 1, 2023
Processing time: 65 Days and 23.9 Hours
Core Tip
Core Tip: This review articles covers all the points related to p53 gene suppression in the pathogenesis of hepatocellular carcinoma. The review manuscript also includes information about tumour suppressor P53, pathogenesis of P53-associated hepatocellular carcinoma (HCC), role of P53 in mechanisms of hepatocarcinogenesis, roles of P53 in extrinsic factor-induced liver carcinogenesis, relationship between hepatitis C virus core protein and P53 in HCC, other mechanisms of progression to cirrhosis and HCC.