Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Jan 22, 2022; 13(1): 34-40
Published online Jan 22, 2022. doi: 10.4291/wjgp.v13.i1.34
Published online Jan 22, 2022. doi: 10.4291/wjgp.v13.i1.34
Combined antrum and corpus biopsy protocol improves Helicobacter pylori culture success
Denise E Brennan, Colm O'Morain, Deirdre McNamara, Sinead M Smith, Department of Clinical Medicine, Trinity College Dublin, Trinity Centre, Tallaght University Hospital, Dublin D24, Ireland
Author contributions: McNamara D conceived the study; Brennan DE and Smith SM performed experiments, acquired and analysed data; O’Morain C and McNamara D recruited patients and collected samples; Smith SM prepared the manuscript; all authors critically reviewed the manuscript and approved the final version; Smith SM and McNamara D contributed equally.
Supported by Health Research Board , No. HRA-POR-2014-526, and No. APA-2019-030.
Institutional review board statement: The study was reviewed and approved by the Joint Research Ethics Committee of St. James’s Hospital and Tallaght University Hospital.
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sinead M Smith, BSc, PhD, Assistant Professor, Department of Clinical Medicine, Trinity College Dublin, Trinity Centre, Tallaght University Hospital, Tallaght, Dublin D24, Ireland. smithsi@tcd.ie
Received: July 23, 2021
Peer-review started: July 23, 2021
First decision: October 3, 2021
Revised: October 16, 2021
Accepted: January 14, 2022
Article in press: January 14, 2022
Published online: January 22, 2022
Peer-review started: July 23, 2021
First decision: October 3, 2021
Revised: October 16, 2021
Accepted: January 14, 2022
Article in press: January 14, 2022
Published online: January 22, 2022
Core Tip
Core Tip: Helicobacter pylori (H. pylori) antimicrobial susceptibility testing is critical to accurately detect antimicrobial resistance, thereby influencing appropriate treatment choices, promoting antimicrobial stewardship and increasing H. pylori eradication rates. However, H. pylori culture represents a challenge and is limited to a small number of specialized centres and reference laboratories. Increasing biopsy sample number has been suggested to improve culture success, but data directly comparing dual biopsy vs single biopsy sample collection for H. pylori culture are lacking. Here we show that combined corpus and antrum biopsy sampling improves H. pylori culture success compared to single antrum biopsy sampling.