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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Dec 12, 2020; 11(6): 114-130
Published online Dec 12, 2020. doi: 10.4291/wjgp.v11.i6.114
Published online Dec 12, 2020. doi: 10.4291/wjgp.v11.i6.114
Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases
Andreas Muehler, Jason R Slizgi, Hella Kohlhof, Manfred Groeppel, Evelyn Peelen, Daniel Vitt, Immunic, AG, Gräfelfing 82166, Germany
Author contributions: Muehler A, Slizgi JR, Kohlhof H, Groeppel M, Peelen E, and Vitt D reviewed and evaluated the literature for inclusion in the review in different therapeutic areas; Muehler A and Slizgi JR prepared the initial draft of the manuscript; Muehler A, Slizgi JR, Kohlhof H, Groeppel M, Peelen E and Vitt D reviewed, edited and approved the final version of the manuscript.
Conflict-of-interest statement: Dr. Muehler and other co-authors report a relationship with Immunic AG (stock, stock options, employment), with drug development projects relevant to this work. In addition, Immunic AG has licensed patent WO 2008/138943 A2 which is part of the development projects in the area of gastrointestinal diseases. Other authors have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andreas Muehler, MD, Chief Medical Officer, Immunic, AG, Lochhamer Schlag 21, Gräfelfing 82166, Germany. andreas.muehler@imux.com
Received: July 21, 2020
Peer-review started: July 21, 2020
First decision: September 24, 2020
Revised: October 7, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: December 12, 2020
Processing time: 143 Days and 5.8 Hours
Peer-review started: July 21, 2020
First decision: September 24, 2020
Revised: October 7, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: December 12, 2020
Processing time: 143 Days and 5.8 Hours
Core Tip
Core Tip: Intestinal barrier dysfunction is an underlying pathophysiological feature in many gastrointestinal diseases. Understanding barrier dysfunction may help drive a deeper understanding of gastrointestinal pathology and identify novel way(s) to manage and/or treat disease. Here, we summarize the evidence supporting intestinal barrier dysfunction in common immune-mediated gastrointestinal diseases and its clinical relevance.