Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Feb 15, 2017; 8(1): 1-2
Published online Feb 15, 2017. doi: 10.4291/wjgp.v8.i1.1
Published online Feb 15, 2017. doi: 10.4291/wjgp.v8.i1.1
Impaired inactivation of digestive proteases: The possible key factor for the high susceptibility of germ-free and antibiotic-treated animals to gut epithelial injury
Xiaofa Qin, GI Biopharma Inc, Westfield, NJ 07090, United States
Author contributions: Qin X contributes solely to this paper.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiaofa Qin, MD, PhD, GI Biopharma Inc, 918 Willow Grove Road, Westfield, NJ 07090, United States. xiaofa_qin@yahoo.com
Telephone: +1-908-4637423
Received: October 9, 2016
Peer-review started: October 11, 2016
First decision: December 13, 2016
Revised: December 16, 2016
Accepted: January 2, 2017
Article in press: January 3, 2017
Published online: February 15, 2017
Processing time: 124 Days and 13.6 Hours
Peer-review started: October 11, 2016
First decision: December 13, 2016
Revised: December 16, 2016
Accepted: January 2, 2017
Article in press: January 3, 2017
Published online: February 15, 2017
Processing time: 124 Days and 13.6 Hours
Abstract
Recent study shows that germ-free and antibiotic-treated animals are highly susceptible to gut epithelial injury. This paper addresses that impaired inactivation of digestive proteases may be the key factor for the increased susceptibility.
Core tip: This paper addresses that impaired inactivation of digestive proteases may be the possible key factor for the high susceptibility of germ-free and antibiotic-treated animals to gut epithelial injury.