Wijarnpreecha K, Nissaisorakarn P, Sornprom S, Thongprayoon C, Thamcharoen N, Maneenil K, Podboy AJ, Cheungpasitporn W. Hepatitis C infection and renal cell carcinoma: A systematic review and meta-analysis. World J Gastrointest Pathophysiol 2016; 7(4): 314-319 [PMID: 27895977 DOI: 10.4291/wjgp.v7.i4.314]
Corresponding Author of This Article
Wisit Cheungpasitporn, MD, Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. wcheungpasitporn@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Karn Wijarnpreecha, Suthanya Sornprom, Charat Thongprayoon, Natanong Thamcharoen, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States
Pitchaphon Nissaisorakarn, Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, United States
Kunlatida Maneenil, Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, United States
Alexander J Podboy, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, United States
Wisit Cheungpasitporn, Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: All authors had access to the data and a role in writing the manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wisit Cheungpasitporn, MD, Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. wcheungpasitporn@gmail.com
Telephone: +1-507-2848450 Fax: +1-507-2667891
Received: April 6, 2016 Peer-review started: April 8, 2016 First decision: May 19, 2016 Revised: July 30, 2016 Accepted: August 17, 2016 Article in press: August 18, 2016 Published online: November 15, 2016 Processing time: 221 Days and 5.9 Hours
Abstract
AIM
To investigate the association between hepatitis C virus (HCV) infection and risk of renal cell carcinoma (RCC).
METHODS
A literature search was performed from inception until February 2016. Studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratio comparing the risk of RCC among HCV-infected participants vs those without HCV infection were included. Participants without HCV infection were used as comparators. Pooled odds ratios and 95%CI were calculated using a random-effect, generic inverse variance method.
RESULTS
Seven observational studies were with 196826 patients were included in the analysis to assess the risk of RCC in patients with HCV. A significantly increased risk of RCC among participants with HCV infection was found with a pooled RR of 1.86 (95%CI: 1.11-3.11). The association between RCC and HCV was marginally insignificant after a sensitivity analysis limited only to studies with adjusted analysis, with a pooled RR of 1.50 (95%CI: 0.93-2.42).
CONCLUSION
Our study demonstrated a potential association between HCV infection and RCC. Further studies of RCC surveillance in patients with HCV are required.
Core tip: Hepatitis C virus (HCV) is a leading cause of cirrhosis in the United States with a steadily increasing prevalence over the past two decades. Interestingly, HCV infection may also be associated with an increased risk of renal cell carcinoma (RCC) as observed in several epidemiologic studies. To further investigate this possible association, we conducted this systematic review and meta-analysis of observational studies reporting the risk of RCC among HCV-infected patients. We found a significantly increased risk of RCC among participants with HCV infection with the pooled risk ratio of 1.86 (95%CI: 1.11-3.11).
