Bhavsar T, Wang C, Huang Y, Karachristos A, Inniss S. Littoral cell angiomas of the spleen associated with solid pseudopapillary tumor of the pancreas. World J Gastrointest Pathophysiol 2011; 2(3): 53-56 [PMID: 21860837 DOI: 10.4291/wjgp.v2.i3.53]
Corresponding Author of This Article
Tapan Bhavsar, MD, PhD, Department of Pathology and Laboratory Medicine, Temple University Hospital, 3401 N Broad St, Philadelphia, PA 19140, United States. tapan.bhavsar@tuhs.temple.edu
Article-Type of This Article
Case Report
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World J Gastrointest Pathophysiol. Jun 15, 2011; 2(3): 53-56 Published online Jun 15, 2011. doi: 10.4291/wjgp.v2.i3.53
Littoral cell angiomas of the spleen associated with solid pseudopapillary tumor of the pancreas
Tapan Bhavsar, Congli Wang, Yajue Huang, Andreas Karachristos, Susan Inniss
Tapan Bhavsar, Congli Wang, Yajue Huang, Susan Inniss, Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA 19140, United States
Andreas Karachristos, Department of Surgery, Temple University Hospital, Philadelphia, PA 19140, United States
Author contributions: Bhavsar T conceived the case report, acquired the patient data, searched the literature and drafted the manuscript; Wang C performed the gross examination of the specimen and made revisions to the manuscript; Huang Y performed and evaluated fine needle aspiration cytology, helped with the histopathological evaluation of the specimen and made revisions to the manuscript; Karachristos A operated on the patient, helped with the gross examination, made revisions to the manuscript and sought patient consent for this case report; and Inniss S helped with the gross examination, performed the histopathological and immunohistochemical evaluation of the specimen and made critical revisions to the manuscript. All authors read and approved the final manuscript.
Correspondence to: Tapan Bhavsar, MD, PhD, Department of Pathology and Laboratory Medicine, Temple University Hospital, 3401 N Broad St, Philadelphia, PA 19140, United States. tapan.bhavsar@tuhs.temple.edu
Telephone: +1-215-707-3923 Fax: +1-215-707-2738
Received: December 21, 2010 Revised: March 31, 2011 Accepted: April 7, 2011 Published online: June 15, 2011
Abstract
Littoral cell angiomas (LCA) of the spleen are vascular tumors of unknown etiology arising from the littoral cells of the splenic red pulp sinuses. Usually a benign and incidental finding, LCA have been repeatedly reported in association with a variety of visceral malignancies and hold the potential for dissemination per se. We encountered a case of a 30 year old female who was diagnosed with solid pseudopapillary tumor of the head and distal pancreas by fine needle aspiration cytology. A distal pancreatectomy with splenectomy was performed in addition to a pylorus-preserving Whipple’s procedure and cholecystectomy. Histopathological examination confirmed solid pseudopapillary tumor of the pancreas and showed multiple well-circumscribed anastomosing vascular channels in the spleen. The diagnosis of LCA of the spleen was confirmed by immunohistochemistry that revealed co-expression of endothelial cell marker, CD31 and CD34, along with histiocytic marker, CD68 by the vascular lining cells. LCA has been previously reported in association with colorectal and pancreatic adenocarcinoma, malignant lymphoma, myelodysplasia and autoimmune disorders. We report the first case of LCA associated with solid pseudopapillary tumor of the pancreas.
