Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Jun 28, 2016; 8(6): 594-599
Published online Jun 28, 2016. doi: 10.4329/wjr.v8.i6.594
Does computed tomography permeability predict hemorrhagic transformation after ischemic stroke?
Peggy Yen, Allison Cobb, Jai Jai Shiva Shankar
Peggy Yen, Allison Cobb, Jai Jai Shiva Shankar, Department of Diagnostic Radiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia B3K 6A3, Canada
Author contributions: Yen P, Cobb A and Shankar JJS performed the research; Yen P and Cobb A collected the data; Yen P and Shankar JJS designed the research and wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Nova Scotia Health Authority Research Ethics Board (CDHA-RS/2013-233).
Informed consent statement: The Nova Scotia Health Authority Research Ethics Board approved a waiver of consent form for this retrospective review. Participants were not required to give informed consent for the use of their data.
Conflict-of-interest statement: The authors have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jai Jai Shiva Shankar, MD, Associate Professor of Medicine, Department of Diagnostic Radiology, Queen Elizabeth II Health Sciences Centre, P.O. Box 9000, Halifax, Nova Scotia B3K 6A3, Canada. shivajai1@gmail.com
Telephone: +1-902-4890577 Fax: +1-902-4732018
Received: October 24, 2015
Peer-review started: October 27, 2015
First decision: February 2, 2016
Revised: February 13, 2016
Accepted: March 22, 2016
Article in press: March 23, 2016
Published online: June 28, 2016
Processing time: 238 Days and 15.9 Hours
Core Tip

Core tip: Hemorrhagic transformation is one of the most important complications following thrombolytic treatment of acute ischemic stroke (AIS). Predicting hemorrhagic complication at presentation can be useful to clinicians. Perfusion-derived permeability-surface area product maps (PS) may help in predicting hemorrhagic transformation. We investigated whether PS can predict hemorrhagic transformation on follow-up. We found that pretreatment PS can predict the occurrence of hemorrhagic transformation on follow-up of AIS patients with relatively high sensitivity, specificity, positive and negative predictive value. However, it cannot predict the degree of severity, which is critical in the decision to treat.