Saeed M, Krug R, Do L, Hetts SW, Wilson MW. Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment. World J Radiol 2016; 8(3): 298-307 [PMID: 27027736 DOI: 10.4329/wjr.v8.i3.298]
Corresponding Author of This Article
Maythem Saeed, PhD, Professor, Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, 185 Berry Street, Suite 350, Campus Box 0946, San Francisco, CA 94107-5705, United States. msaeed@ucsf.edu
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Radiol. Mar 28, 2016; 8(3): 298-307 Published online Mar 28, 2016. doi: 10.4329/wjr.v8.i3.298
Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment
Maythem Saeed, Roland Krug, Loi Do, Steven W Hetts, Mark W Wilson
Maythem Saeed, Roland Krug, Loi Do, Steven W Hetts, Mark W Wilson, Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, San Francisco, CA 94107-5705, United States
Author contributions: Saeed M designed the study, performed the experiments, analyzed MR images/histology and wrote the manuscript; Krug R performed the ablation and MR imaging and involved in manuscript editing; Do L achieved and analyzed the images, prepared the figures and involved in manuscript editing; Hetts SW and Wilson MW provided vital advices and were also involved in manuscript editing.
Institutional animal care and use committee statement: This study received approval from Institutional Animal Care and Use Committee.
Conflict-of-interest statement: All investigators have no conflict-of-interest.
Data sharing statement: The authors are solely responsible for the data.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Maythem Saeed, PhD, Professor, Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, 185 Berry Street, Suite 350, Campus Box 0946, San Francisco, CA 94107-5705, United States. msaeed@ucsf.edu
Telephone: +1-415-5146221 Fax: +1-415-3539423
Received: June 26, 2015 Peer-review started: July 7, 2015 First decision: September 11, 2015 Revised: October 23, 2015 Accepted: November 13, 2015 Article in press: November 17, 2015 Published online: March 28, 2016 Processing time: 269 Days and 7 Hours
Core Tip
Core tip: Renal carcinoma constitutes the majority of kidney malignancies. The gold standard procedure for treatment of renal carcinoma remains surgical excision. However, in a large number of patients, surgical excision is precluded by increased perioperative risk due to medical comorbidities. Recent innovations in the field of thermal ablation procedures and real-time imaging have accelerated the development of magnetic resonance-guided high intensity focused ultrasound (MRg-HIFU). This study showed that contrast enhanced magnetic resonance imaging (MRI) provides good assessment of renal ablation created noninvasively by MRg-HIFU. The volume and depth of ablated tissue depends on the applied energy and number of sonications. Histopathology demonstrated coagulation necrosis and vascular damage in the ablated tissue and confirmed the volume of damage seen on contrast enhanced MRI.
