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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Jul 28, 2014; 6(7): 486-492
Published online Jul 28, 2014. doi: 10.4329/wjr.v6.i7.486
Published online Jul 28, 2014. doi: 10.4329/wjr.v6.i7.486
Nuclear imaging in detection and monitoring of cardiotoxicity
Carmen D’Amore, Stefania Paolillo, Angela Maria Pellegrino, Tiziana Formisano, Antonio Mariniello, Giuseppe Della Ratta, Elisabetta Iardino, Marianna D’Amato, Lucia La Mura, Irma Fabiani, Flavia Fusco, Pasquale Perrone Filardi, Department of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy
Paola Gargiulo, SDN Foundation, Institute of Diagnostic and Nuclear Development, 80129 Naples, Italy
Author contributions: D’Amore C and Gargiulo P contributed to this work, generated the tables and wrote the manuscript; Paollillo S, Pellegrino AM, Formisano T and Mariniello A contributed to the writing of the manuscript; Della Ratta G, Iardino E, D’Amato M, La Mura L, Fabiani I and Fusco F contributed to med-line; and Perrone Filardi P reviewed the manuscript.
Correspondence to: Pasquale Perrone Filardi, MD, PhD, Department of Advanced Biomedical Sciences, Federico II University, Via Pansini, 5, 80131 Naples, Italy. fpperron@unina.it
Telephone: +39-81-7462224 Fax: +39-81-7462224
Received: February 21, 2014
Revised: April 21, 2014
Accepted: May 29, 2014
Published online: July 28, 2014
Revised: April 21, 2014
Accepted: May 29, 2014
Published online: July 28, 2014
Core Tip
Core tip: Cardiomyopathy is a potential complication of various anticancer drugs, such as anthracyclines and biological therapy. Left ventricular dysfunction is the most common manifestation of cardiotoxicity and is monitored with left ventricular ejection fraction measurement, but it is a late manifestation of myocardial injury. Thus, the cardiologist and oncologist should collaborate to identify new non-invasive techniques to detect cardiac dysfunction at an early and potentially reversible stage, before the onset of clinical manifestation. To achieve this aim, nuclear imaging techniques may offer good future perspectives for early detection of myocardial damage using novel molecular tracers.