Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Sep 28, 2024; 16(9): 460-465
Published online Sep 28, 2024. doi: 10.4329/wjr.v16.i9.460
Behcet's disease-related panuveitis following COVID-19 vaccination: A case report
Rou-Ting Lin, Pei-Kang Liu, Chia-Wei Chang, Kai-Chun Cheng, Kuo-Jen Chen, Yo-Chen Chang
Rou-Ting Lin, School of Medicine, College of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Rou-Ting Lin, Chia-Wei Chang, Department of Clinical Education and Training, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
Pei-Kang Liu, Kai-Chun Cheng, Yo-Chen Chang, Department of Ophthalmology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80737, Taiwan
Pei-Kang Liu, Kai-Chun Cheng, Yo-Chen Chang, Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
Kuo-Jen Chen, Yo-Chen Chang, Department of Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 81201, Taiwan
Author contributions: Lin RT and Chang YC were the major contributor in writing the manuscript and reviewing the literature; Liu PK, Chang CW, Cheng KC, and Chen KJ created the figures and patient images; Chang YC was the chief physician of the patient. All authors revised the manuscript and approved the final version.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this case report.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest for this paper.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yo-Chen Chang, MD, PhD, Associate Professor, Chief Physician, Department of Ophthalmology, School of Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Zihyou 1st Road, San-Ming District, Kaohsiung 80737, Taiwan. ycchang@kmu.edu.tw
Received: May 25, 2024
Revised: August 15, 2024
Accepted: August 23, 2024
Published online: September 28, 2024
Processing time: 124 Days and 17 Hours
Core Tip

Core Tip: This case report highlights a rare instance of panuveitis as the first manifestation of Behcet's disease in a 30-year-old man following mRNA-based coronavirus disease 2019 vaccination (Moderna). The patient developed recurrent uveitis after both doses of the vaccine. This case suggests a potential link between mRNA vaccines and ocular inflammation in genetically predisposed individuals, particularly those with HLA-B51. It underscores the importance of considering Behcet's disease in patients presenting with panuveitis post-vaccination and calls for further research to confirm this association and understand the underlying mechanisms.