Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Sep 28, 2024; 16(9): 418-428
Published online Sep 28, 2024. doi: 10.4329/wjr.v16.i9.418
Nomogram for predicting short-term response to anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration: An observational study
Zhen-Huan Huang, Xue-Zhao Tu, Qi Lin, Mei Tu, Guo-Cai Lin, Kai-Ping Zhang
Zhen-Huan Huang, Qi Lin, Department of Radiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China
Xue-Zhao Tu, Department of Orthopedics, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China
Mei Tu, Department of Endocrinology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China
Guo-Cai Lin, Kai-Ping Zhang, Department of Ophthalmology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China
Author contributions: Huang ZH and Lin GC conceived and designed the study; Huang ZH, Zhang KP, and Tu XZ collected and assembled the data; Huang ZH, Tu XZ, Lin Q, and Tu M analyzed and interpreted the data. All authors have read and approved the final manuscript.
Supported by Fujian Province Natural Science Foundation of China, No. 2020J011321.
Institutional review board statement: The study was reviewed and approved by the Longyan First Affiliated Hospital of Fujian Medical University (approval No. 202014).
Informed consent statement: As this retrospective observational study used anonymous clinical data from patients who have already consented to treatment, no additional consent was needed. Patients were informed of potential research use at the time of treatment consent.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Huan Huang, MD, Associate Chief Physician, Department of Radiology, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 North 91 Road, Xinluo District, Longyan 364000, Fujian Province, China. tuxuezhao@163.com
Received: May 7, 2024
Revised: August 12, 2024
Accepted: August 14, 2024
Published online: September 28, 2024
Processing time: 142 Days and 12.5 Hours
Core Tip

Core Tip: This study developed a predictive model using optical coherence tomography angiography to identify factors affecting the effectiveness of anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration (nAMD). The number of junction voxels emerged as an independent predictor of positive treatment outcomes. Integrating several parameters, the predictive model demonstrated strong performance in forecasting 1-mo therapeutic outcomes, providing a valuable tool for personalized treatment planning in nAMD patients.