Prospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Dec 28, 2024; 16(12): 771-781
Published online Dec 28, 2024. doi: 10.4329/wjr.v16.i12.771
Proposed computed tomography severity index for the evaluation of invasive fungal sinusitis: Preliminary results
Smita Manchanda, Ashu S Bhalla, Ankita D Nair, Kapil Sikka, Hitesh Verma, Alok Thakar, Aanchal Kakkar, Maroof A Khan
Smita Manchanda, Ashu S Bhalla, Ankita D Nair, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi 110029, India
Kapil Sikka, Hitesh Verma, Alok Thakar, Department of Otorhinolaryngology and Skull Base Surgery, All India Institute of Medical Sciences, New Delhi 110029, India
Aanchal Kakkar, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India
Maroof A Khan, Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India
Author contributions: Manchanda S and Bhalla AS designed the research study; Sikka K, Verma H, and Thakar A contributed to case referral and later follow-up of the cases; Nair AD contributed to data acquisition and organization; Manchanda S analyzed the data and wrote the manuscript; Nair AD also assisted in the editing of the manuscript; Kakkar A contributed to histopathological analysis; Khan MA participated in the study design and performed the statistical analysis; all authors have read and approved the final manuscript.
Supported by All India Institute of Medical Sciences, New Delhi, No. A-COVID-80.
Institutional review board statement: The study was reviewed and approved by the All India Institute of Medical Sciences, New Delhi Institutional Review Board (IEC -378/02.07.2021).
Clinical trial registration statement: No clinical registration statement applies to this study.
Informed consent statement: All study participants, or their legal guardian, provided written consent before study enrolment.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at ashubhalla2@gmail.com. Participants gave informed consent for data sharing.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ashu S Bhalla, MD, Professor, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Sri Aurobindo Marg, New Delhi 110029, India. ashubhalla1@yahoo.com
Received: June 5, 2024
Revised: October 24, 2024
Accepted: December 3, 2024
Published online: December 28, 2024
Processing time: 205 Days and 8 Hours
Core Tip

Core Tip: This was a prospective study with 66 coronavirus disease 2019-positive patients in whom contrast-enhanced computed tomography (CECT) of the paranasal sinuses was done for invasive fungal sinusitis (IFS). It aimed to propose a scoring system [computed tomography severity index (CTSI)] using CECT to describe the severity of IFS and correlate it with clinical outcomes. Disease was categorized as mild, moderate, and severe based on CTSI. A higher score correlated with slow response/non-response to treatment in our study. Thus, CTSI can help in the quantification of the disease burden, triaging patients, and response assessment. A higher score would alert the clinician to initiate aggressive treatment, as severe disease correlates with slow response/non-response to treatment.