Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Nov 28, 2023; 15(11): 315-323
Published online Nov 28, 2023. doi: 10.4329/wjr.v15.i11.315
Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters
Winn Aung, Atsushi B Tsuji, Kazuaki Rikiyama, Fumihiko Nishikido, Satoshi Obara, Tatsuya Higashi
Winn Aung, Atsushi B Tsuji, Kazuaki Rikiyama, Satoshi Obara, Tatsuya Higashi, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
Fumihiko Nishikido, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
Author contributions: Aung W conceptualized and designed the study; Aung W, Rikiyama K and Nishikido F conducted the experiments and analyzed the data; Obara S performed the subtraction image processing; Aung W and Tsuji AB wrote the manuscript; Tsuji AB and Higashi T coordinated the research and contributed to manuscript preparation; all authors contributed to manuscript revision; All authors read and approved the final manuscript.
Supported by Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science, No. 21K07740.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of National Institutes for Quantum Science and Technology, No. 07-1064-28. No animals or animal-derived samples or patients or patient-derived samples were included in this study.
Conflict-of-interest statement: The authors declare no potential conflicts of interest for this article.
Data sharing statement: All relevant data were presented in the manuscript. Further information is available from the corresponding author at winn.aung@qst.go.jp.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Received: October 3, 2023
Peer-review started: October 3, 2023
First decision: October 17, 2023
Revised: October 26, 2023
Accepted: November 17, 2023
Article in press: November 17, 2023
Published online: November 28, 2023
Processing time: 51 Days and 15.9 Hours
Core Tip

Core Tip: Radionuclides produce Cherenkov radiation (CR), which can potentially activate photosensitizers (PSs) in phototherapy. However, a cost-effective method to determine whether radionuclide-derived CR excites PSs and the measurement of fluorescence emitted by excited PS remain elusive. We propose a cost-effective method using a charge-coupled device optical imaging system combined with long-pass filters and subtraction image processing to distinguish CR and PS fluorescence emission. As a proof-of-concept, 64CuCl2 and the PS tetrakis (4-carboxyphenyl) porphyrin were used in the experiments. This method can contribute to accelerating the development of Cherenkov energy transfer imaging and the discovery of new PSs.