Wang YT, Yan X, Pu H, Yin LL. In vivo evaluation of early renal damage in type 2 diabetic patients on 3.0 T MR diffusion tensor imaging. World J Radiol 2018; 10(8): 83-90 [PMID: 30190800 DOI: 10.4329/wjr.v10.i8.83]
Corresponding Author of This Article
Yu-Ting Wang, MD, Department of Radiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China. wangyuting_330@163.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Radiol. Aug 28, 2018; 10(8): 83-90 Published online Aug 28, 2018. doi: 10.4329/wjr.v10.i8.83
In vivo evaluation of early renal damage in type 2 diabetic patients on 3.0 T MR diffusion tensor imaging
Yu-Ting Wang, Xiong Yan, Hong Pu, Long-Lin Yin
Yu-Ting Wang, Xiong Yan, Hong Pu, Long-Lin Yin, Department of Radiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China
Author contributions: Wang YT designed the main ideas and wrote the paper; Yan X, Pu H and Yin LL helped collect relevant data.
Supported bythe Fundamental Research Funds for the Central Universities, University of Electronic Science and Technology of China, No. ZYGX2015J125.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Sichuan Provincial People’s Hospital.
Conflict-of-interest statement: The authors declare no conflicts of interests.
Open-Access: This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yu-Ting Wang, MD, Department of Radiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China. wangyuting_330@163.com
Telephone: +86-28-87394725
Received: May 3, 2018 Peer-review started: May 4, 2018 First decision: June 6, 2018 Revised: June 26, 2018 Accepted: July 10, 2018 Article in press: July 10, 2018 Published online: August 28, 2018 Processing time: 117 Days and 20.2 Hours
Core Tip
Core tip: Early diagnosis of diabetic nephropathy (DN) facilitates timely treatment, and therefore, improves patient outcomes. Microalbuminuria (MAU), a standard biomarker of DN, has limited sensitivity and reproducibility. Diffusion tensor imaging (DTI) quantifies the directional nature of water diffusion and is especially suited for highly oriented organs such as the kidney. DTI parameter changes were reported in several renal pathologic conditions. This study exhibited reductions of renal fractional anisotropy (FA) in diabetic patients, even with normoalbuminuria, which raises the possibility of detecting early DN with higher sensitivity than MAU. Furthermore, renal FA demonstrated statistical correlation with eGFR, making it a potential functional biomarker.
