Kazci O, Ege F, Aydemir H, Kazci S, Aydin S. Can the change of vasomotor activity in irritable bowel syndrome patients be detected via color Doppler ultrasound? World J Radiol 2023; 15(7): 226-233 [PMID: 37545646 DOI: 10.4329/wjr.v15.i7.226]
Corresponding Author of This Article
Sonay Aydin, MD, PhD, Academic Editor, Associate Professor, Department of Radiology, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Başbağlar, Hacı Ali Akın Cd. No. 32, 24100 Erzincan Merkez/Erzincan, Erzincan 24400, Turkey. sonay.aydin@erzincan.edu.tr
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Omer Kazci, Department of Radiology, Ankara Training and Research Hospital, Ankara 06600, Turkey
Fahrettin Ege, Department of Neurology, VM Medicalpark Hospital, Ankara 06600, Turkey
Huseyin Aydemir, Sonay Aydin, Department of Radiology, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Erzincan 24400, Turkey
Saliha Kazci, Department of Epidemiology, Ankara University Faculty of Medicine, Ankara 06600, Turkey
Author contributions: Kazci O, Ege F, and Kazci S contributed equally to this work; Aydemir H wrote the manuscript; Aydin S, Kazci S, and Kazci O performed the experiments; Aydemir H and Ege F provided technical support and suggestions; Aydin S participated in writing and modifying the manuscript; Kazci O designed the study; All authors approved the final manuscript.
Institutional review board statement: The studies adhered to the most recent edition of the Declaration of Helsinki, and the Ankara City Hospital No. 2 Clinical Research Ethics Committee authorized the procedures, No. E2-22-1307.
Informed consent statement: The participants signed a declaration form declaring that all participants and/or their legal guardians granted informed permission.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sonay Aydin, MD, PhD, Academic Editor, Associate Professor, Department of Radiology, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Başbağlar, Hacı Ali Akın Cd. No. 32, 24100 Erzincan Merkez/Erzincan, Erzincan 24400, Turkey. sonay.aydin@erzincan.edu.tr
Received: April 25, 2023 Peer-review started: April 25, 2023 First decision: June 19, 2023 Revised: June 20, 2023 Accepted: July 7, 2023 Article in press: July 7, 2023 Published online: July 28, 2023 Processing time: 89 Days and 23.6 Hours
ARTICLE HIGHLIGHTS
Research background
Irritable bowel syndrome (IBS) is one of the most common illnesses referred to the gastrointestinal outpatient clinic. The pathophysiology of IBS is not completely understood. One of the pathophysiologies is visceral hypersensitivity. The sympathetic nervous system is primarily responsible for managing the arteries, and its consequence is vasospasm in the medium and large arteries, which results in decreased blood flow.
Research motivation
Our impetus came from our study's adoption of a novel approach to assess changes in vasomotor activity in IBS patients.
Research objectives
We wanted to employ a different way to determine the change in vasomotor activity in persons with IBS in our study.
Research methods
The diameter and flow velocities of the brachial artery were determined using a probe with Doppler examination at the diameter of the antecubital fossa. To activate the sympathetic fibers, bipolar stimulation was applied to the median nerve at the wrist. Brachial artery diameter and flow velocities were assessed again immediately after the fifth stimulation.
Research results
In our study, a statistically significant decrease was found in brachial artery flow velocity and diameter after sympathetic stimulation in healthy individuals without a history of chronic disease. In patients with IBS, a statistically significant increase was found in brachial artery flow velocity and diameter after sympathetic stimulation.
Research conclusions
As a result, sympathetic activation reduces artery width and blood flow in healthy people. In people with IBS, it has the opposite effect. Detection of changes in brachial artery diameter and flow velocity by Doppler examination is thought to be more useful and comfortable than other methods described in the literature.
Research perspectives
It has been discovered that the autonomic activity of persons suffering from IBS differs from that of healthy people. Colored Doppler ultrasonography can be used as a noninvasive diagnostic method that can be conducted at any age, is comfortable for the patient, and does not require additional patient compliance in patients with IBS.
