Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Jul 28, 2023; 15(7): 226-233
Published online Jul 28, 2023. doi: 10.4329/wjr.v15.i7.226
Can the change of vasomotor activity in irritable bowel syndrome patients be detected via color Doppler ultrasound?
Omer Kazci, Fahrettin Ege, Huseyin Aydemir, Saliha Kazci, Sonay Aydin
Omer Kazci, Department of Radiology, Ankara Training and Research Hospital, Ankara 06600, Turkey
Fahrettin Ege, Department of Neurology, VM Medicalpark Hospital, Ankara 06600, Turkey
Huseyin Aydemir, Sonay Aydin, Department of Radiology, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Erzincan 24400, Turkey
Saliha Kazci, Department of Epidemiology, Ankara University Faculty of Medicine, Ankara 06600, Turkey
Author contributions: Kazci O, Ege F, and Kazci S contributed equally to this work; Aydemir H wrote the manuscript; Aydin S, Kazci S, and Kazci O performed the experiments; Aydemir H and Ege F provided technical support and suggestions; Aydin S participated in writing and modifying the manuscript; Kazci O designed the study; All authors approved the final manuscript.
Institutional review board statement: The studies adhered to the most recent edition of the Declaration of Helsinki, and the Ankara City Hospital No. 2 Clinical Research Ethics Committee authorized the procedures, No. E2-22-1307.
Informed consent statement: The participants signed a declaration form declaring that all participants and/or their legal guardians granted informed permission.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sonay Aydin, MD, PhD, Academic Editor, Associate Professor, Department of Radiology, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Başbağlar, Hacı Ali Akın Cd. No. 32, 24100 Erzincan Merkez/Erzincan, Erzincan 24400, Turkey. sonay.aydin@erzincan.edu.tr
Received: April 25, 2023
Peer-review started: April 25, 2023
First decision: June 19, 2023
Revised: June 20, 2023
Accepted: July 7, 2023
Article in press: July 7, 2023
Published online: July 28, 2023
Processing time: 89 Days and 23.6 Hours
ARTICLE HIGHLIGHTS
Research background

Irritable bowel syndrome (IBS) is one of the most common illnesses referred to the gastrointestinal outpatient clinic. The pathophysiology of IBS is not completely understood. One of the pathophysiologies is visceral hypersensitivity. The sympathetic nervous system is primarily responsible for managing the arteries, and its consequence is vasospasm in the medium and large arteries, which results in decreased blood flow.

Research motivation

Our impetus came from our study's adoption of a novel approach to assess changes in vasomotor activity in IBS patients.

Research objectives

We wanted to employ a different way to determine the change in vasomotor activity in persons with IBS in our study.

Research methods

The diameter and flow velocities of the brachial artery were determined using a probe with Doppler examination at the diameter of the antecubital fossa. To activate the sympathetic fibers, bipolar stimulation was applied to the median nerve at the wrist. Brachial artery diameter and flow velocities were assessed again immediately after the fifth stimulation.

Research results

In our study, a statistically significant decrease was found in brachial artery flow velocity and diameter after sympathetic stimulation in healthy individuals without a history of chronic disease. In patients with IBS, a statistically significant increase was found in brachial artery flow velocity and diameter after sympathetic stimulation.

Research conclusions

As a result, sympathetic activation reduces artery width and blood flow in healthy people. In people with IBS, it has the opposite effect. Detection of changes in brachial artery diameter and flow velocity by Doppler examination is thought to be more useful and comfortable than other methods described in the literature.

Research perspectives

It has been discovered that the autonomic activity of persons suffering from IBS differs from that of healthy people. Colored Doppler ultrasonography can be used as a noninvasive diagnostic method that can be conducted at any age, is comfortable for the patient, and does not require additional patient compliance in patients with IBS.