Peer-review started: July 27, 2015
First decision: September 22, 2015
Revised: October 5, 2015
Accepted: November 24, 2015
Article in press: November 25, 2015
Published online: January 28, 2016
Processing time: 183 Days and 20.6 Hours
AIM: To investigate the frequency of anatomical variations in sinonasal region and association of these variations with mucosal diseases.
METHODS: The study included 400 cases (191 female and 209 male) who were considered to have preliminary diagnoses of sinonasal pathology and who had paranasal sinus computed tomography (CT) examination in axial plane. Reformatted CT images were studied in all planes.
RESULTS: Age range of the patients was 20-83 (mean 40.26 ± 14.85). Most commonly detected anatomical variation was Agger nasi cell (74.8%). There was a significant association between clinoid process pneumatization and protrusion of internal carotid arteries and optic nerves into sphenoid sinus (P < 0.001). Besides, the relationships between pterygoid process pneumatization and protrusion of vidian nerve into sphenoid sinus, and between pneumatization of large sphenoid wing and protrusion of maxillary nerves into sphenoid sinus were also significant (P < 0.001). Uncinate bulla and giant ethmoid bulla were found to be significantly associated with sinonasal mucosal diseases (P = 0.004 and P = 0.002, respectively).
CONCLUSION: Sinonasal region has a great number of variations, and some of them have been determined to be associated with sinonasal mucosal disease. It is necessary to know that some of these variations are associated with protrusion of significant structures such as carotid artery or optic nerve into the sinus and care should be observed in surgeries on patients carrying these variations.
Core tip: Currently paranasal sinus computed tomography is routinely used to detect anatomy and pathologies of nasal cavity and paranasal sinuses. Sinonasal region has a great number of variations, and some of them have been determined to be associated with sinonasal mucosal disease. It is necessary to know that some of these variations are associated with protrusion of significant structures such as carotid artery, optic nerve, vidian nerve and maxillary nerve into the sphenoid sinus and care should be observed in surgeries on patients carrying these variations.