Treechairusame T, Taweesedt PT. Carbon ion radiation therapy in prostate cancer: The importance of dosage. World J Radiol 2024; 16(11): 696-699 [DOI: 10.4329/wjr.v16.i11.696]
Corresponding Author of This Article
Pahnwat T Taweesedt, MD, Instructor, Postdoctoral Fellow, Department of Psychiatry and Behavioral Sciences, Stanford University, No. 401 Quarry Road, Stanford, CA 94305, United States. pahnwatt@stanford.edu
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Radiol. Nov 28, 2024; 16(11): 696-699 Published online Nov 28, 2024. doi: 10.4329/wjr.v16.i11.696
Carbon ion radiation therapy in prostate cancer: The importance of dosage
Teeradon Treechairusame, Pahnwat T Taweesedt
Teeradon Treechairusame, Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Pahnwat T Taweesedt, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States
Pahnwat T Taweesedt, Sierra Pacific Mental Illness Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA 94304, United States
Author contributions: Treechairusame T and Taweesedt PT contributed to this paper; Treechairusame T designed the overall concept and outline of the manuscript; Taweesedt T contributed to the discussions; Treechairusame T and Taweesedt PT contributed to the writing, and editing the manuscript, and review of the literature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pahnwat T Taweesedt, MD, Instructor, Postdoctoral Fellow, Department of Psychiatry and Behavioral Sciences, Stanford University, No. 401 Quarry Road, Stanford, CA 94305, United States. pahnwatt@stanford.edu
Received: August 9, 2024 Revised: October 11, 2024 Accepted: November 1, 2024 Published online: November 28, 2024 Processing time: 110 Days and 7 Hours
Abstract
In this article, we comment on the article by Ono et al. We focus specifically on the carbon ion radiotherapy studies and the method to calculate the dosing schedule. While photon hypofractionated radiotherapy in prostate cancer has demonstrated improvement in tumor control with reduced gastrointestinal toxicity compared to conventional radiotherapy, carbon ion radiotherapy (CIRT) offers additional physical and biological advantages. Recent findings, including those from Ono et al, have established new dose constraints of CIRT for prostate cancer treatment and risk factors for rectal bleeding. Due to limited data on CIRT dosing, this study underscores the need for more research to refine dose calculation methods and better understand their effects on clinical outcomes.
Core Tip: Carbon ion radiotherapy (CIRT) is widely implemented for many cancer types, including prostate cancer. Gastrointestinal toxicity, particularly rectal bleeding, is a notable risk of radiotherapy. The knowledge of CIRT dosage is crucial as it may impact the risk of rectal bleeding.
