Liu LH, Zhang HW, Zhang HB, Liu XL, Deng HZ, Lin F, Huang B. Distinctive magnetic resonance imaging features in primary central nervous system lymphoma: A case report. World J Radiol 2023; 15(9): 274-280 [PMID: 37823021 DOI: 10.4329/wjr.v15.i9.274]
Corresponding Author of This Article
Han-Wen Zhang, MD, Doctor, Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, No. 3002 Sungangxi Road, Shenzhen 518036, Guangdong Province, China. zhwstarcraft@outlook.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Li-Hong Liu, Han-Wen Zhang, Xiao-Lei Liu, Hua-Zhen Deng, Fan Lin, Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, Shenzhen 518036, Guangdong Province, China
Han-Wen Zhang, Hong-Bo Zhang, Biao Huang, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510282, Guangdong Province, China
Hong-Bo Zhang, Department of Radiology, Sun Yat-Sen University, Shenzhen 518000, Guangdong Province, China
Biao Huang, Department of Radiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, Guangdong Province, China
Author contributions: Case studies were provided by Liu LH; Zhang HW wrote the article; Deng HZ searched the literature; Zhang HB analyzed the case; Huang B and Lin F revised and reviewed the manuscript; Huang B (huangbiao@gdph.org.cn), Lin F (foxetfoxet@gmail.com), and Zhang HW contributed equally to this research.
Supported byNational Natural Science Foundation of China, No. 82071871; Guangdong Basic and Applied Basic Research Foundation, No. 2021A1515220131; Guangdong Medical Science and Technology Research Fund Project, No. 2022111520491834; and Clinical Research Project of Shenzhen Second People's Hospital, China, No. 20223357022.
Informed consent statement: The patient signed an informed consent to the publication of this case.
Conflict-of-interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Han-Wen Zhang, MD, Doctor, Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, No. 3002 Sungangxi Road, Shenzhen 518036, Guangdong Province, China. zhwstarcraft@outlook.com
Received: June 30, 2023 Peer-review started: June 30, 2023 First decision: August 24, 2023 Revised: September 4, 2023 Accepted: September 22, 2023 Article in press: September 22, 2023 Published online: September 28, 2023 Processing time: 88 Days and 17.8 Hours
Abstract
BACKGROUND
Primary central nervous system lymphoma (PCNSL) is a rare malignant tumor originating from the lymphatic hematopoietic system. It exhibits unique imaging manifestations due to its biological characteristics.
CASE SUMMARY
Magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), and magnetic resonance spectroscopy was performed. The imaging findings showed multiple space-occupying lesions with low signal on T1-weighted imaging, uniform high signal on T2-weighted imaging, and obvious enhancement on contrast-enhanced scans. DWI revealed diffusion restriction, PWI demonstrated hypoperfusion, and spectroscopy showed elevated choline peak and decreased N-acetylaspartic acid. The patient's condition significantly improved after hormone shock therapy.
CONCLUSION
This case highlights the distinctive imaging features of PCNSL and their importance in accurate diagnosis and management.
Core Tip: Primary central nervous system lymphoma (PCNSL) is a rare tumor of the central nervous system with distinctive imaging features. This case report highlights the imaging manifestations of multiple PCNSL lesions using diffusion-weighted imaging, perfusion-weighted imaging, and magnetic resonance imaging. Accurate diagnosis is crucial for appropriate management. Further research and larger studies are needed to enhance the understanding and diagnostic accuracy of PCNSL.
