Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Jul 28, 2020; 12(7): 137-141
Published online Jul 28, 2020. doi: 10.4329/wjr.v12.i7.137
Convalescent plasma therapy in a pregnant COVID-19 patient with a dramatic clinical and imaging response: A case report
Ramezan Jafari, Nematollah Jonaidi-Jafari, Fatemeh Dehghanpoor, Amin Saburi
Ramezan Jafari, Radiology Department, Faculty of Medicine and Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran 18151777, Iran
Nematollah Jonaidi-Jafari, Health Research Center and Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran 18151777, Iran
Fatemeh Dehghanpoor, Radiology Department, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran 18151777, Iran
Amin Saburi, Chemical Injuries Research Center and Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran 18151777, Iran
Author contributions: Jafari R took part in the data acquisition, supervision of the study, and writing, review and editing of the manuscript; Jonaidi-Jafari N was involved in project administration, and writing of the original draft; Dehghanpoor F was involved in data acquisition, and writing of the primary draft; Saburi A took part in data acquisition, supervision of the study, and writing, review and editing of the manuscript.
Informed consent statement: Informed consent from the patient in this case report was obtained.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Amin Saburi, MD, Academic Research, Doctor, Postdoc, Senior Researcher, Chemical Injuries Research Center and Faculty of Medicine, Baqiyatallah University of Medical Sciences, Mollasadra St, Vanak Sq, Tehran 18151777, Iran. aminsaburi@yahoo.com
Received: April 27, 2020
Peer-review started: April 27, 2020
First decision: May 15, 2020
Revised: June 14, 2020
Accepted: June 17, 2020
Article in press: June 17, 2020
Published online: July 28, 2020
Processing time: 86 Days and 8.7 Hours
Abstract
BACKGROUND

Coronavirus disease 2019 (COVID-19) is a novel very contagious infection which was designated a pandemic in all countries of the world in April 2020. Its presentation varies from mild to severe infection, but the majority of infected patients have mild manifestations. Many therapeutic choices have been suggested to treat the infection, but none are fully effective.

CASE SUMMARY

Herein we present a 26-year-old woman with a twin pregnancy at 36 wk and one day gestation with confirmed COVID-19 who responded dramatically to convalescent plasma therapy (CPT) and Favipiravir.

CONCLUSION

Although this case report shows the efficacy of CPT in addition to usual medications used for COVID-19, there are many questions that need to be answered regarding dosage, para-clinical efficacy, side effects and combination therapy.

Keywords: Case report; Convalescent plasma therapy; Pregnancy; COVID-19; Favipiravir; Radiologic findings

Core tip: This is one of the first reports on the efficacy of convalescent plasma therapy (CPT) in a pregnant patient with coronavirus disease 2019 (COVID-19) pneumonia. Chest computed tomography scan findings and clinical parameters showed a dramatic response to the combination of Favipiravir and CPT, which may be an important choice for pregnant patients with COVID-19 pneumonia.