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Odd D, Sabir H, Jones SA, Gale C, Chakkarapani E. Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study. Pediatr Res 2024; 96:785-791. [PMID: 38565915 PMCID: PMC11499269 DOI: 10.1038/s41390-024-03157-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/01/2023] [Revised: 12/21/2023] [Accepted: 03/02/2024] [Indexed: 04/04/2024]
Abstract
BACKGROUND To determine the association between early infection risk factors and short-term outcomes in infants with neonatal encephalopathy following perinatal asphyxia (NE). METHODS A retrospective population-based cohort study utilizing the National Neonatal Research Database that included infants with NE admitted to neonatal units in England and Wales, Jan 2008-Feb 2018. EXPOSURE one or more of rupture of membranes >18 h, maternal group B streptococcus colonization, chorioamnionitis, maternal pyrexia or antepartum antibiotics. PRIMARY OUTCOME death or nasogastric feeds/nil by mouth (NG/NBM) at discharge. SECONDARY OUTCOMES organ dysfunction; length of stay; intraventricular hemorrhage; antiseizure medications use. RESULTS 998 (13.7%) out of 7265 NE infants had exposure to early infection risk factors. Primary outcome (20.3% vs. 23.1%, OR 0.87 (95% CI 0.71-1.08), p = 0.22), death (12.8% vs. 14.0%, p = 0.32) and NG/NBM (17.4% vs. 19.9%. p = 0.07) did not differ between the exposed and unexposed group. Time to full sucking feeds (OR 0.81 (0.69-0.95)), duration (OR 0.82 (0.71-0.95)) and the number of antiseizure medications (OR 0.84 (0.72-0.98)) were lower in exposed than unexposed infants after adjusting for confounders. Therapeutic hypothermia did not alter the results. CONCLUSIONS Infants with NE exposed to risk factors for early-onset infection did not have worse short-term adverse outcomes. IMPACT Risk factors for early-onset neonatal infection, including rupture of membranes >18 h, maternal group B streptococcus colonization, chorioamnionitis, maternal pyrexia or antepartum antibiotics, were not associated with death or short-term morbidity after cooling for NE. Despite exposure to risk factors for early-onset neonatal infection, infants with NE reached oral feeds earlier and needed fewer anti-seizure medications for a shorter duration than infants with NE but without such risk factors. This study supports current provision of therapeutic hypothermia for infants with NE and any risk factors for early-onset neonatal infection.
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Affiliation(s)
- David Odd
- Cardiff University, The School of Medicine, Cardiff, UK
| | - Hemmen Sabir
- Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, 53127, Bonn, Germany
| | - Simon A Jones
- Cardiff University, The School of Medicine, Cardiff, UK
| | - Chris Gale
- Neonatal Medicine, School of Public Health, Imperial College London, London, UK
| | - Ela Chakkarapani
- Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
- St Michael's Hospital Neonatal Intensive Care Unit, University Hospitals Bristol & Weston NHS Foundation Trust, Bristol, UK.
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2
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Prial J, El-Shibiny H, El-Dib M, Benjamin J, Erdei C, Dodrill P, Szakmar E, Bell KA. Growth trajectories and need for oral feeding support among infants with neonatal encephalopathy treated with therapeutic hypothermia. J Perinatol 2024; 44:1163-1171. [PMID: 38702507 DOI: 10.1038/s41372-024-01983-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/29/2023] [Revised: 04/16/2024] [Accepted: 04/18/2024] [Indexed: 05/06/2024]
Abstract
OBJECTIVE Identify feeding supports required among infants with neonatal encephalopathy and determine growth trajectories to 3 years. STUDY DESIGN Single-center retrospective cohort study of 120 infants undergoing therapeutic hypothermia. Logistic regression and stratified analyses identified whether clinical factors, EEG-determined encephalopathy severity, and MRI-based brain injury predict feeding supports (nasogastric tube, oral feeding compensations) and growth. RESULTS 50.8% of infants required feeding supports in the hospital, decreasing to 14% at discharge. Moderate-to-severe encephalopathy and basal ganglia injury predicted feeding support needs. Yet, 35% of mildly encephalopathic infants required gavage tubes. Growth trajectories approximated expected growth of healthy infants. CONCLUSION Infants with neonatal encephalopathy-even if mild-frequently experience feeding difficulties during initial hospitalization. With support, most achieve full oral feeds by discharge and adequate early childhood growth. Clinical factors may help identify infants requiring feeding support, but do not detect all at-risk infants, supporting routine screening of this high-risk population.
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Affiliation(s)
- Jennifer Prial
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA
| | - Hoda El-Shibiny
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA
| | - Mohamed El-Dib
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA
- Harvard Medical School, Boston, MA, USA
| | - Jennifer Benjamin
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA
- Harvard Medical School, Boston, MA, USA
| | - Carmina Erdei
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA
- Harvard Medical School, Boston, MA, USA
| | - Pamela Dodrill
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA
- Harvard Medical School, Boston, MA, USA
| | - Eniko Szakmar
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA
- Division of Neonatology, Pediatric Center, Semmelweis University, Budapest, Hungary
| | - Katherine A Bell
- Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA.
- Harvard Medical School, Boston, MA, USA.
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3
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Sugg JN, Lee JW. Neurologic Dysphagia. Otolaryngol Clin North Am 2024; 57:599-608. [PMID: 38664090 DOI: 10.1016/j.otc.2024.03.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 07/01/2024]
Abstract
Dysphagia is commonly associated with neurologic/neuromuscular disorders including prematurity, cerebral palsy, traumatic brain injury, brain tumors, genetic disorders, and neuromuscular diseases. This article aims to review the major categories of neurologic dysphagia, to outline specific findings and special considerations for each population, and to acknowledge the importance of integrating each patient's medical prognosis, goals of care, and developmental stage into a multidisciplinary treatment plan.
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Affiliation(s)
- Jillian Nyswonger Sugg
- Department of Head and Neck Surgery & Communication Sciences, Division of Speech Pathology and Audiology, Duke University, DUMC 3887, Durham, NC 27710, USA
| | - Janet Waimin Lee
- Department of Head and Neck Surgery & Communication Sciences, Division of Pediatric Otolaryngology, Duke University, DUMC 3805, Durham, NC 27710, USA.
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4
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Takle M, Conaway M, Burnsed J. Electroencephalogram Background Predicts Time to Full Oral Feedings in Hypoxic-Ischemic Encephalopathy. Am J Perinatol 2022; 39:1678-1681. [PMID: 33657637 DOI: 10.1055/s-0041-1725161] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 10/22/2022]
Abstract
OBJECTIVE Infants with a history of neonatal hypoxic-ischemic encephalopathy (HIE) are at risk for oral motor dysfunction. Previous studies have associated the need for gastrostomy tube at neonatal intensive care unit discharge with brainstem injury on magnetic resonance imaging (MRI). However, the factors associated with time to full oral feeds in this population have not been previously described. This study aimed to study factors associated with time to full oral feeds in this population. STUDY DESIGN This is a single-center, retrospective study that examined these factors using Cox regression. RESULTS A total of 150 infants who received therapeutic hypothermia from 2011 to 2017 were included in this study. The single clinical factor significantly associated with time to full oral feeds was the severity of background abnormality on electroencephalogram in the first 24 hours of age (severe vs. mild 95% confidence interval [CI]: 0.34-0.74; moderate vs. mild 95% CI: 0.19-0.45). Brainstem injury on MRI was the factor most highly associated with need for gastrostomy tube placement (p = 0.028), though the overall incidence of need for gastrostomy tube feeds in this population was low (5%). CONCLUSION These findings may help clinicians counsel families on what to expect in neonates with HIE and make decisions on the need for and timing to pursue gastrostomy tube in this population. KEY POINTS · The overall incidence of the need for assisted feeding at NICU discharge is low in this population.. · MRI brainstem injury was most highly associated with need for gastrostomy tube placement.. · Worsening severity of background abnormality on EEG was associated with longer time to oral feeds..
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Affiliation(s)
- Mrinmayee Takle
- Children's National Hospital Child Neurology Residency Program, Washington, District of Columbia
| | - Mark Conaway
- Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia
| | - Jennifer Burnsed
- Department of Pediatrics, University of Virginia, Charlottesville, Virginia.,Department of Neurology, University of Virginia, Charlottesville, Virginia
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Bhagat I, Agarwal P, Sarkar A, Dechert R, Altinok D, Chouthai N. Does Severity of Brain Injury on Magnetic Resonance Imaging Predict Short-Term Outcome in Neonates Who Received Therapeutic Hypothermia? Am J Perinatol 2021; 40:666-671. [PMID: 34102692 DOI: 10.1055/s-0041-1730431] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 10/21/2022]
Abstract
OBJECTIVE The National Institute of Child Health and Human Development (NICHD) magnetic resonance imaging (MRI) pattern of brain injury is a known biomarker of childhood outcome following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE). However, usefulness of this classification has not been evaluated to predict short-term outcomes. The study aimed to test the hypothesis that infants with NICHD MRI pattern of severe hypoxic-ischemic brain injury will be sicker with more severe asphyxia-induced multiorgan dysfunction resulting in prolonged length of stay (LOS) following therapeutic hypothermia. We also evaluated the role of other risk factors which may prolong LOS. STUDY DESIGN We retrospectively reviewed the medical records of 71 consecutively cooled neonates to examine the ability of MRI patterns of brain injury to predict the LOS. A neuroradiologist masked to outcomes classified the patterns of brain injury on MRI as per NICHD. Pattern 2A (basal ganglia thalamic, internal capsule, or watershed infarction), 2B (2A with cerebral lesions), and 3 (hemispheric devastation) of brain injury was deemed "severe injury." RESULTS Out of 71 infants, 59 surviving infants had both MRI and LOS data. LOS was higher for infants who had Apgar's score of ≤5 at 10 minutes, severe HIE, seizures, coagulopathy, or needed vasopressors or inhaled nitric oxide, or had persistent feeding difficulty, or remained intubated following cooling. However, median LOS did not differ between the infants with and without MRI pattern of severe injury (15 days, interquartile range [IQR]: 9-28 vs. 12 days, IQR: 10-20; p = 0.4294). On multivariate linear regression analysis, only persistent feeding difficulty (β coefficient = 11, p = 0.001; or LOS = 11 days longer if had feeding difficulty) and ventilator days (β coefficient 1.7, p < 0.001; or LOS increased 1.7 times for each day of ventilator support) but not the severity of brain injury predicted LOS. CONCLUSION Unlike neurodevelopmental outcome, LOS is not related to severity of brain injury as defined by the NICHD. KEY POINTS · The NICHD pattern of brain injury on MRI predicts neurodevelopmental outcome following hypothermia treatment for neonatal HIE.. · LOS did not differ between the infants with and without MRI patterns of severe injury.. · The severity of brain injury as defined by the NICHD was not predictive of the LOS following therapeutic hypothermia..
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Affiliation(s)
- Indira Bhagat
- Neonatal-Perinatal Medicine, Children's Hospital of Michigan, Detroit, Michigan
| | - Prashant Agarwal
- Neonatal-Perinatal Medicine, Children's Hospital of Michigan, Detroit, Michigan
| | | | - Ronald Dechert
- University of Michigan Health System, Ann Arbor, Michigan
| | - Deniz Altinok
- Neonatal-Perinatal Medicine, Children's Hospital of Michigan, Detroit, Michigan
| | - Nitin Chouthai
- Neonatal-Perinatal Medicine, Children's Hospital of Michigan, Detroit, Michigan
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6
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Sarkar SS, Gupta S, Bapuraj JR, Dechert RE, Sarkar S. Brainstem hypoxic-ischemic lesions on MRI in infants treated with therapeutic cooling: effects on the length of stay and mortality. J Perinatol 2021; 41:512-518. [PMID: 33223525 DOI: 10.1038/s41372-020-00873-y] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/01/2020] [Revised: 09/25/2020] [Accepted: 11/04/2020] [Indexed: 11/09/2022]
Abstract
OBJECTIVE To test the hypothesis that brainstem hypoxic-ischemic injury on magnetic resonance imaging (MRI) would be independently associated with short-term outcomes in cooled asphyxiated infants. METHODS A total of 90 consecutively cooled asphyxiated infants who survived to have brain MRI were reviewed. A neuroradiologist who was masked to outcomes evaluated MRI images for brainstem involvement. Outcomes were mortality and length of stay. RESULTS Brainstem lesions were present on post-cooling brain MRI in 20 of the 90 infants (22%). Overall, four infants died before discharge, and all four had brainstem involvement. The infants with brainstem involvement had longer hospital stay (29 days, IQR 20-47 versus 16 days, IQR 10-26; P = 0.0001), compared to infants without brainstem lesions (n = 70); and upon multivariate analysis, brainstem involvement remained independently associated with prolonged hospital stay (β = 12.4, P = 0.001). CONCLUSION This study demonstrates the importance of recognizing brainstem injury for the prediction of short-term outcomes in cooled asphyxiated infants.
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Affiliation(s)
| | - Suneeti Gupta
- Neonatal-Perinatal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
| | | | - Ronald E Dechert
- Neonatal-Perinatal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
| | - Subrata Sarkar
- Neonatal-Perinatal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
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7
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Shandley S, Capilouto G, Tamilia E, Riley DM, Johnson YR, Papadelis C. Abnormal Nutritive Sucking as an Indicator of Neonatal Brain Injury. Front Pediatr 2021; 8:599633. [PMID: 33511093 PMCID: PMC7835320 DOI: 10.3389/fped.2020.599633] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/27/2020] [Accepted: 11/24/2020] [Indexed: 12/27/2022] Open
Abstract
A term neonate is born with the ability to suck; this neuronal network is already formed and functional by 28 weeks gestational age and continues to evolve into adulthood. Because of the necessity of acquiring nutrition, the complexity of the neuronal network needed to suck, and neuroplasticity in infancy, the skill of sucking has the unique ability to give insight into areas of the brain that may be damaged either during or before birth. Interpretation of the behaviors during sucking shows promise in guiding therapies and how to potentially repair the damage early in life, when neuroplasticity is high. Sucking requires coordinated suck-swallow-breathe actions and is classified into two basic types, nutritive and non-nutritive. Each type of suck has particular characteristics that can be measured and used to learn about the infant's neuronal circuitry. Basic sucking and swallowing are present in embryos and further develop to incorporate breathing ex utero. Due to the rhythmic nature of the suck-swallow-breathe process, these motor functions are controlled by central pattern generators. The coordination of swallowing, breathing, and sucking is an enormously complex sensorimotor process. Because of this complexity, brain injury before birth can have an effect on these sucking patterns. Clinical assessments allow evaluators to score the oral-motor pattern, however, they remain ultimately subjective. Thus, clinicians are in need of objective measures to identify the specific area of deficit in the sucking pattern of each infant to tailor therapies to their specific needs. Therapeutic approaches involve pacifiers, cheek/chin support, tactile, oral kinesthetic, auditory, vestibular, and/or visual sensorimotor inputs. These therapies are performed to train the infant to suck appropriately using these subjective assessments along with the experience of the therapist (usually a speech therapist), but newer, more objective measures are coming along. Recent studies have correlated pathological sucking patterns with neuroimaging data to get a map of the affected brain regions to better inform therapies. The purpose of this review is to provide a broad scope synopsis of the research field of infant nutritive and non-nutritive feeding, their underlying neurophysiology, and relationship of abnormal activity with brain injury in preterm and term infants.
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Affiliation(s)
- Sabrina Shandley
- Jane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, United States
| | - Gilson Capilouto
- Department of Communication Sciences and Disorders, University of Kentucky, Lexington, KY, United States
- NFANT Labs, LLC, Marietta, GA, United States
| | - Eleonora Tamilia
- Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States
| | - David M. Riley
- Neonatal Intensive Care Unit, Cook Children's Health Care System, Fort Worth, TX, United States
- School of Medicine, Texas Christian University and University of North Texas Health Science Center, Fort Worth, TX, United States
| | - Yvette R. Johnson
- Neonatal Intensive Care Unit, Cook Children's Health Care System, Fort Worth, TX, United States
- School of Medicine, Texas Christian University and University of North Texas Health Science Center, Fort Worth, TX, United States
- Neonatal Intensive Care Unit Early Support and Transition (NEST), Developmental Follow-Up Center, Neonatology Department, Cook Children's Health Care System, Fort Worth, TX, United States
| | - Christos Papadelis
- Jane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, United States
- Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States
- School of Medicine, Texas Christian University and University of North Texas Health Science Center, Fort Worth, TX, United States
- Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States
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8
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Pineda R, Prince D, Reynolds J, Grabill M, Smith J. Preterm infant feeding performance at term equivalent age differs from that of full-term infants. J Perinatol 2020; 40:646-654. [PMID: 32066844 PMCID: PMC7117861 DOI: 10.1038/s41372-020-0616-2] [Citation(s) in RCA: 22] [Impact Index Per Article: 4.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/04/2019] [Revised: 01/21/2020] [Accepted: 02/04/2020] [Indexed: 11/17/2022]
Abstract
OBJECTIVE To identify differences in feeding skill performance among preterm infants at term equivalent age compared with full-term infants. STUDY DESIGN Ninety-two infants (44 preterm infants born ≤32 weeks gestation at term equivalent age and 48 full-term infants within 4 days of birth) had a standardized oral feeding assessment. RESULT Preterm infants at term equivalent age had lower Neonatal Eating Outcome Assessment scores (67.8 ± 13.6 compared with 82.2 ± 8.1; p < 0.001) and were more likely to have poor arousal (p = 0.04), poor tongue positioning (p = 0.04), suck-swallow-breathe discoordination (p < 0.001), inadequate sucking bursts (p = 0.01), tonal abnormalities (p < 0.001), discoordination of the jaw and tongue during sucking (p < 0.001), lack of positive engagement with the feeder and/or discomfort (p < 0.001), signs of aspiration (p < 0.001), difficulty regulating breathing (p < 0.001), and have an inability to maintain an appropriate state (p < 0.001), and complete the feeding (<0.001). CONCLUSION A broad range of feeding-related difficulties appear to remain evident in preterm infants at term equivalent age.
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Affiliation(s)
- Roberta Pineda
- Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA. .,Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. .,University of Southern California, Chan Division of Occupational Science and Occupational Therapy, Keck School of Medicine-Pediatrics, California, USA.
| | - Danielle Prince
- 0000 0001 2355 7002grid.4367.6Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO USA
| | - Jenny Reynolds
- 0000 0001 2167 9807grid.411588.1Baylor University Hospital, Division of Baylor Scott & White Rehabilitation Hospital, Dallas, TX USA
| | - Molly Grabill
- 0000 0001 2355 7002grid.4367.6Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO USA
| | - Joan Smith
- 0000 0000 9953 7617grid.416775.6Department of Quality, Safety, and Practice Excellence, Saint Louis Children’s Hospital, St. Louis, MO USA
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Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes. Sci Rep 2019; 9:16406. [PMID: 31712561 PMCID: PMC6848138 DOI: 10.1038/s41598-019-52563-1] [Citation(s) in RCA: 22] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/09/2019] [Accepted: 10/11/2019] [Indexed: 11/18/2022] Open
Abstract
Long-term operations carried out at high altitude (HA) by military personnel, pilots, and astronauts may trigger health complications. In particular, chronic exposure to high altitude (CEHA) has been associated with deficits in cognitive function. In this study, we found that mice exposed to chronic HA (5000 m for 12 weeks) exhibited deficits in learning and memory associated with hippocampal function and were linked with changes in the expression of synaptic proteins across various regions of the brain. Specifically, we found decreased levels of synaptophysin (SYP) (p < 0.05) and spinophilin (SPH) (p < 0.05) in the olfactory cortex, post synaptic density−95 (PSD-95) (p < 0.05), growth associated protein 43 (GAP43) (p < 0.05), glial fibrillary acidic protein (GFAP) (p < 0.05) in the cerebellum, and SYP (p < 0.05) and PSD-95 (p < 0.05) in the brainstem. Ultrastructural analyses of synaptic density and morphology in the hippocampus did not reveal any differences in CEHA mice compared to SL mice. Our data are novel and suggest that CEHA exposure leads to cognitive impairment in conjunction with neuroanatomically-based molecular changes in synaptic protein levels and astroglial cell marker in a region specific manner. We hypothesize that these new findings are part of highly complex molecular and neuroplasticity mechanisms underlying neuroadaptation response that occurs in brains when chronically exposed to HA.
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10
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Tamilia E, Parker MS, Rocchi M, Taffoni F, Hansen A, Grant PE, Papadelis C. Nutritive sucking abnormalities and brain microstructural abnormalities in infants with established brain injury: a pilot study. J Perinatol 2019; 39:1498-1508. [PMID: 31462720 DOI: 10.1038/s41372-019-0479-6] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/01/2019] [Revised: 06/14/2019] [Accepted: 07/20/2019] [Indexed: 01/06/2023]
Abstract
OBJECTIVE To determine the relationship between nutritive sucking and microstructural integrity of sensorimotor tracts in newborns with brain injury. STUDY DESIGN Diffusion imaging was performed in ten newborns with brain injury. Nutritive sucking was assessed using Nfant®. The motor, sensory, and corpus callosum tracts were reconstructed via tractography. Fractional anisotropy, radial, axial, and mean diffusivity were estimated for these tracts. Multiple regression models were developed to test the association between sucking features and diffusion parameters. RESULTS Low-sucking smoothness correlated with low-fractional anisotropy of motor tracts (p = 0.0096). High-sucking irregularity correlated with high-mean diffusivity of motor (p = 0.030) and corpus callosum tracts (p = 0.032). For sensory tracts, high-sucking irregularity (p = 0.018) and low-smoothness variability (p = 0.002) correlated with high-mean diffusivity. INTERPRETATION We show a correlation between neuroimaging-demonstrated microstructural brain abnormalities and variations in sucking patterns of newborns. The consistency of this relationship should be shown on larger cohorts.
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Affiliation(s)
- Eleonora Tamilia
- Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.,Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
| | - Marianna S Parker
- Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
| | - Maria Rocchi
- Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.,Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
| | - Fabrizio Taffoni
- Laboratory of Biomedical Robotics and Biomicrosystems, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Anne Hansen
- Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
| | - P Ellen Grant
- Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
| | - Christos Papadelis
- Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. .,Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. .,Jane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, USA.
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11
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Colleti Junior J, Koga W, Carvalho WBD. SÍNDROME POSTERIOR DO TRONCO CEREBRAL E O USO DE VENTILAÇÃO ASSISTIDA AJUSTADA NEURALMENTE (NAVA) EM LACTENTE. REVISTA PAULISTA DE PEDIATRIA 2017; 36:4. [PMID: 28977137 PMCID: PMC5849368 DOI: 10.1590/1984-0462/;2018;36;1;00003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 10/24/2016] [Accepted: 03/26/2017] [Indexed: 11/21/2022]
Abstract
Objective: To report a rare case of dorsal brainstem syndrome in an infant after
hypoxic-ischemic episode due to severe sepsis and the use of neurally adjusted
ventilatory assist (NAVA) to aid in diagnosis and in the removal of mechanical
ventilation. Case description: A 2-month-old male infant, previously healthy, presented with severe sepsis that
evolved to dorsal brainstem syndrome, which usually occurs after hypoxic-ischemic
injury in neonates and infants, and is related to very specific magnetic resonance
images. Due to neurological lesions, thei nfant remained in mechanical
ventilation. A NAVA module was installed to keep track of phrenic nerve conduction
to the diaphragm, having successfully showed neural conduction and helped removing
mechanical ventilation. Comments: Dorsal brainstem syndrome is a rare condition that should be considered after
hypoxic-ischemic episode in infants.
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12
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Sanchez K, Morgan AT, Slattery JM, Olsen JE, Lee KJ, Anderson PJ, Thompson DK, Doyle LW, Cheong JLY, Spittle AJ. Neuropredictors of oromotor feeding impairment in 12month-old children. Early Hum Dev 2017; 111:49-55. [PMID: 28595097 DOI: 10.1016/j.earlhumdev.2017.05.012] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2016] [Revised: 04/07/2017] [Accepted: 05/30/2017] [Indexed: 11/29/2022]
Abstract
BACKGROUND Feeding impairment is prevalent in children with neurodevelopmental issues. Neuroimaging and neurobehavioral outcomes at term are predictive of later neuromotor impairment, but it is unknown whether they predict feeding impairment. AIMS To determine whether neurobehavior and brain magnetic resonance imaging (MRI) at term predict oromotor feeding at 12 months in preterm and term-born children. STUDY DESIGN Prospective cohort study. SUBJECTS 248 infants (97 born <30 weeks and 151 born at term) recruited at birth. OUTCOME MEASURES Neurobehavioral assessments (General Movements (GMA), Hammersmith Neonatal Neurological Examination (HNNE), Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS)); and brain MRI were administered at term-equivalent age. Oromotor feeding was assessed at 12 months corrected age using the Schedule for Oral Motor Assessment. RESULTS 49/227 children had oromotor feeding impairment. Neurobehavior associated with later feeding impairment was: suboptimal NNNS stress (odds ratio [OR] 2.68; 95% confidence interval [CI] 1.20–6.01), non-optimal reflexes (OR 3.33; 95% CI 1.37–8.11) and arousal scales (OR 2.54; 95% CI 1.03–6.27); suboptimal HNNE total (OR 4.69; 95% CI 2.20–10.00), reflexes (OR 2.62; 95% CI 1.06–6.49), and tone scores (OR 3.87; 95% CI 1.45–10.35); and abnormal GMA (OR 2.60; 95% CI 1.21–5.57). Smaller biparietal diameter also predicted feeding impairment (OR 0.88; 95% CI 0.79–0.97). There was little evidence that relationships differed between birth groups. CONCLUSIONS Neurobehavior and biparietal diameter at term are associated with oromotor feeding at 12 months. These results may identify children at greatest risk of oromotor feeding impairment.
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Affiliation(s)
- Katherine Sanchez
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia.
| | - Angela T Morgan
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia; Royal Children's Hospital, Parkville, VIC 3052, Australia.
| | | | - Joy E Olsen
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; Royal Women's Hospital, Parkville, VIC 3052, Australia.
| | - Katherine J Lee
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia.
| | - Peter J Anderson
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia.
| | - Deanne K Thompson
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.
| | - Lex W Doyle
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia; Royal Women's Hospital, Parkville, VIC 3052, Australia.
| | - Jeanie L Y Cheong
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia; Royal Women's Hospital, Parkville, VIC 3052, Australia.
| | - Alicia J Spittle
- Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia; Royal Women's Hospital, Parkville, VIC 3052, Australia.
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Quattrocchi CC, Fariello G, Longo D. Brainstem tegmental lesions in neonates with hypoxic-ischemic encephalopathy: Magnetic resonance diagnosis and clinical outcome. World J Radiol 2016; 8:117-123. [PMID: 26981220 PMCID: PMC4770173 DOI: 10.4329/wjr.v8.i2.117] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/31/2015] [Revised: 10/11/2015] [Accepted: 12/11/2015] [Indexed: 02/06/2023] Open
Abstract
Lesions of the brainstem have been reported in the clinical scenarios of hypoxic-ischemic encephalopathy (HIE), although the prevalence of these lesions is probably underestimated. Neuropathologic studies have demonstrated brainstem involvement in severely asphyxiated infants as an indicator of poor outcome. Among survivors to HIE, the most frequent clinical complaints that may be predicted by brainstem lesions include feeding problems, speech, language and communication problems and visual impairments. Clinical series, including vascular and metabolic etiologies, have found selective involvement of the brainstem with the demonstration of symmetric bilateral columnar lesions of the tegmentum. The role of brainstem lesions in HIE is currently a matter of debate, especially when tegmental lesions are present in the absence of supra-tentorial lesions. Differential diagnosis of tegmental lesions in neonates and infants include congenital metabolic syndromes and drug-related processes. Brainstem injury with the presence of supratentorial lesions is a predictor of poor outcome and high rates of mortality and morbidity. Further investigation will be conducted to identify specific sites of the brainstem that are vulnerable to hypoxic-ischemic and toxic-metabolic insults.
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Quattrocchi CC, Errante Y, Rossi Espagnet MC, Galassi S, Della Sala SW, Bernardi B, Fariello G, Longo D. Magnetic resonance imaging differential diagnosis of brainstem lesions in children. World J Radiol 2016; 8:1-20. [PMID: 26834941 PMCID: PMC4731345 DOI: 10.4329/wjr.v8.i1.1] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/31/2015] [Revised: 10/11/2015] [Accepted: 12/11/2015] [Indexed: 02/06/2023] Open
Abstract
Differential diagnosis of brainstem lesions, either isolated or in association with cerebellar and supra-tentorial lesions, can be challenging. Knowledge of the structural organization is crucial for the differential diagnosis and establishment of prognosis of pathologies with involvement of the brainstem. Familiarity with the location of the lesions in the brainstem is essential, especially in the pediatric population. Magnetic resonance imaging (MRI) is the most sensitive and specific imaging technique for diagnosing disorders of the posterior fossa and, particularly, the brainstem. High magnetic static field MRI allows detailed visualization of the morphology, signal intensity and metabolic content of the brainstem nuclei, together with visualization of the normal development and myelination. In this pictorial essay we review the brainstem pathology in pediatric patients and consider the MR imaging patterns that may help the radiologist to differentiate among vascular, toxico-metabolic, infective-inflammatory, degenerative and neoplastic processes. Helpful MR tips can guide the differential diagnosis: These include the location and morphology of lesions, the brainstem vascularization territories, gray and white matter distribution and tissue selective vulnerability.
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15
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Baudon JJ, Renault F, Flores-Guevara R, Vazquez MP. Outcomes of Neonatal Bulbar Weakness. Pediatrics 2016; 137:peds.2015-3004. [PMID: 26659817 DOI: 10.1542/peds.2015-3004] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 09/30/2015] [Indexed: 11/24/2022] Open
Abstract
BACKGROUND AND OBJECTIVE Neonatal bulbar weakness (BW) has various etiologies and a broad prognostic range. We aimed to report outcomes in a large series of children with neonatal BW and explore the association of orofacial electrodiagnostic data with outcome. METHODS We retrospectively reviewed the files of children who presented with facial, lingual, laryngeal, or pharyngeal weakness at birth and who underwent electrodiagnostic studies combining conventional needle electromyography (EMG) of orofacial muscles, blink responses, and EMG during bottle-feeding. Outcome measures included the need for prolonged respiratory assistance and enteral feeding, as well as sensorimotor and cognitive impairments. RESULTS Of 175 patients, 73% had developmental disorders, 25% suffered from acquired brain damage, and 2% had no apparent underlying disorders. Motor or mental impairment was observed in 71%; death occurred in 16%. Outcomes were not significantly different when comparing developmental disorders versus acquired brain damage or neurogenic versus normal detection EMG. Abnormal blink responses were associated with higher frequencies of respiratory assistance (P = .03), gastrostomy (P = .025), and death (P = .009); moderate or severe oropharyngeal incoordinations were associated with higher frequencies of respiratory assistance (P = .006), prolonged enteral feeding (P < .0001), and gastrostomy (P = .0002). CONCLUSIONS Orofacial electrodiagnostic studies provide supplementary information to help the pediatrician anticipate the management and prognosis of young infants with BW.
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Affiliation(s)
- Jean-Jacques Baudon
- Faculté de Médecine Pierre et Marie Curie, Université Paris 6, Paris, France
| | - Francis Renault
- Clinical Neurophysiology Unit, Hôpital Armand-Trousseau, Assistance Publique - Hôpitaux de Paris, Paris, France;
| | - Roberto Flores-Guevara
- Clinical Neurophysiology Unit, Hôpital Armand-Trousseau, Assistance Publique - Hôpitaux de Paris, Paris, France; Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru
| | - Marie-Paule Vazquez
- Faculté de Médecine René Descartes, Université Paris 5, Paris, France; and Department of Maxillofacial Surgery, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France
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16
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Renault F, Flores-Guevara R, Baudon JJ, Vazquez MP. Congenital multiple cranial neuropathies: Relevance of orofacial electromyography in infants. Muscle Nerve 2015; 52:754-8. [DOI: 10.1002/mus.24636] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/02/2015] [Revised: 02/07/2015] [Accepted: 02/27/2015] [Indexed: 11/10/2022]
Affiliation(s)
- Francis Renault
- Clinical Neurophysiology Unit, Hôpital Armand-Trousseau, Assistance Publique-Hôpitaux de Paris; 28 avenue Arnold-Netter, 75571 Paris 12 France
| | - Roberto Flores-Guevara
- Clinical Neurophysiology Unit, Hôpital Armand-Trousseau, Assistance Publique-Hôpitaux de Paris; 28 avenue Arnold-Netter, 75571 Paris 12 France
- Facultad de Medicina, Universidad Nacional Mayor de San Marcos; Lima Peru
| | | | - Marie-Paule Vazquez
- Faculté de Médecine René-Descartes, Université Paris 5; Paris France
- Department of Maxillofacial Surgery; Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris; Paris France
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17
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Bellot B, Peyronnet-Roux J, Gire C, Simeoni U, Vinay L, Viemari JC. Deficits of brainstem and spinal cord functions after neonatal hypoxia-ischemia in mice. Pediatr Res 2014; 75:723-30. [PMID: 24618565 DOI: 10.1038/pr.2014.42] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/23/2013] [Accepted: 12/30/2013] [Indexed: 01/18/2023]
Abstract
BACKGROUND Perinatal cerebral hypoxia-ischemia (HI) can lead to severe neurodevelopmental disorders. Studies in humans and animal models mainly focused on cerebral outcomes, and little is known about the mechanisms that may affect the brainstem and the spinal cord. Dysfunctions of neuromodulatory systems, such as the serotonergic (5-HT) projections, critical for the development of neural networks, have been postulated to underlie behavioral and motor deficits, as well as metabolic changes. METHODS The aim of this study was to investigate brainstem and spinal cord functions by means of plethysmography and sensorimotor tests in a neonatal Rice-Vanucci model of HI in mice. We also evaluated bioaminergic contents in central regions dedicated to the motor control of autonomic functions. RESULTS Mice with cerebral infarct expressed motor disturbances and had a lower body weight and a decreased respiratory frequency than SHAM, suggesting defects of brainstem neural network involved in the motor control of feeding, suckling, swallowing, and respiration. Moreover, our study revealed changes of monoamine and amino acid contents in the brainstem and the spinal cord of HI mice. CONCLUSION Our results suggest that monoaminergic neuromodulation plays an important role in the physiopathology of HI brain injury that may represent a good therapeutic target.
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Affiliation(s)
- Blandine Bellot
- 1] Institut de Neurosciences de la Timone (P3M Team), UMR 7289, CNRS, Aix Marseille Université, Marseille, France [2] Pôle de Médecine et Réanimation Néonatales, Assistance Publique Hôpitaux de Marseille, Marseille, France
| | - Julie Peyronnet-Roux
- Institut de Neurosciences de la Timone (P3M Team), UMR 7289, CNRS, Aix Marseille Université, Marseille, France
| | - Catherine Gire
- Pôle de Médecine et Réanimation Néonatales, Assistance Publique Hôpitaux de Marseille, Marseille, France
| | - Umberto Simeoni
- 1] Pôle de Médecine et Réanimation Néonatales, Assistance Publique Hôpitaux de Marseille, Marseille, France [2] Aix Marseille Université, Marseille, France
| | - Laurent Vinay
- Institut de Neurosciences de la Timone (P3M Team), UMR 7289, CNRS, Aix Marseille Université, Marseille, France
| | - Jean-Charles Viemari
- Institut de Neurosciences de la Timone (P3M Team), UMR 7289, CNRS, Aix Marseille Université, Marseille, France
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18
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Magnetic resonance imaging in neonates with total asphyxia. Brain Dev 2013; 35:53-60. [PMID: 22583740 DOI: 10.1016/j.braindev.2012.04.002] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/11/2011] [Revised: 04/13/2012] [Accepted: 04/18/2012] [Indexed: 11/20/2022]
Abstract
Magnetic resonance (MR) findings in cases of total asphyxia, whose lesions are mainly in the brainstem and deep nuclei, have not been clarified. In this study, we investigated MR images in neonates with total asphyxia. MR images of six infants (three males and three females; gestational age, 35-39 weeks; birth weights, 1880-3572 g) with total asphyxia were examined. In all subjects, neonatal cortical MR lesions were limited to the hippocampus with highlighting on T1-weighted imaging (T1-WI). The neonatal MR lesions of the cerebral white matter were limited to the white matter between the insula and putamen in four infants, and were diffusely involved in two infants. The ventral lateral nucleus of the thalamus was hyperintense on T1-WI in all of the subjects. Other nuclei in the thalamus, the globus pallidus and the putamen were involved in neonatal MR images of all subjects. High intensity areas on T2- weighted imaging were observed at the dorsal areas in the midbrain, pons and medulla oblongata in all or most of the subjects at the neonatal period. Also, high intensity areas on T1-WI were observed in the tegmentum of the pons and the midbrain in five cases. Neonates with total asphyxia had lesions mainly in the tegmentem of the brainstem, thalamus, putamen and globus palludus. Some of the infants had extensive lesions of the white matter.
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Feeding and communication impairments in infants with central grey matter lesions following perinatal hypoxic-ischaemic injury. Eur J Paediatr Neurol 2012; 16:688-96. [PMID: 22658307 DOI: 10.1016/j.ejpn.2012.05.001] [Citation(s) in RCA: 50] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/10/2011] [Revised: 04/25/2012] [Accepted: 05/01/2012] [Indexed: 01/04/2023]
Abstract
BACKGROUND Basal ganglia and thalamic (BGT) injury is common after acute perinatal hypoxia-ischaemia. Cerebral palsy is the most obvious consequence of BGT injury affecting 70-75% of survivors and is predictable from neonatal magnetic resonance imaging (MRI). However there is no equivalent predictive data for other specific outcomes. Feeding and communication impairments are also common in children following hypoxic-ischaemic encephalopathy (HIE) and BGT injury. AIMS To describe, in infants with HIE and BGT injury, the prevalence of feeding and communication impairments; and to evaluate the accuracy of early MRI for predicting these outcomes. METHODS 175 term infants with HIE and BGT injury were studied. Brain lesions were classified by site and severity from the MRI scans. Motor, feeding and communication impairments were documented at 2 years. RESULTS Feeding and communication impairments occurred in 65% and 82% of 126 survivors respectively and related strongly to the severity of motor impairment. Forty-one children had a gastrostomy or long-term nasogastric tube. Injury severity in all brain regions was significantly associated with feeding and communication impairment on univariate analysis. On logistic regression analysis BGT (OR 10.9) and mesencephalic lesions (OR 3.7) were independently associated with feeding impairment; BGT (OR 10.5) and pontine lesions (OR 3.8) were associated with gastrostomy; the severity of BGT lesions (OR 20.1) was related to the severity of communication impairment. CONCLUSIONS Feeding and communication impairment are very common in children with BGT and brainstem injury of neonatal origin and can be well predicted from early MRI scans.
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Hiyane M, Saito Y, Saito T, Komaki H, Nakagawa E, Sugai K, Sasaki M, Sato N, Yamamoto T, Imai Y. A case of bulbar type cerebral palsy: representative symptoms of dorsal brainstem syndrome. Brain Dev 2012; 34:787-91. [PMID: 22306266 DOI: 10.1016/j.braindev.2012.01.003] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/24/2011] [Revised: 01/11/2012] [Accepted: 01/11/2012] [Indexed: 11/28/2022]
Abstract
In this study, we present the case of a 2-year-old boy who exhibited facial and bulbar paralysis since birth, severe dysphagia, signs of oculomotor disturbance, jaw jerks, pyramidal signs on both toes, intellectual disability, and severe gastroesophageal reflux. His blink reflex and auditory/somatosensory evoked potentials suggested abnormalities in the lower brainstem, and magnetic resonance imaging showed a T2 hyperintense area in the pontine tegmentum. These findings combined with the patient's symptoms suggested "dorsal brainstem syndrome" and indicated a possibility of prenatal asphyxia in this patient. Nosologic issues regarding this subgroup of cerebral palsy are discussed here.
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Affiliation(s)
- Masato Hiyane
- Department of Child Neurology, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo, Japan
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Slattery J, Morgan A, Douglas J. Early sucking and swallowing problems as predictors of neurodevelopmental outcome in children with neonatal brain injury: a systematic review. Dev Med Child Neurol 2012; 54:796-806. [PMID: 22607330 DOI: 10.1111/j.1469-8749.2012.04318.x] [Citation(s) in RCA: 48] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/12/2022]
Abstract
AIM Early sucking and swallowing problems may be potential markers of neonatal brain injury and assist in identifying those infants at increased risk of adverse outcomes, but the relation between early sucking and swallowing problems and neonatal brain injury has not been established. The aim of the review was, therefore, to investigate the relation between early measures of sucking and swallowing and neurodevelopmental outcomes in infants diagnosed with neonatal brain injury and in infants born very preterm (<32wks) with very low birthweight (<1500g), at risk of neonatal brain injury. METHOD We conducted a systematic review of English-language articles using CINAHL, EMBASE, and MEDLINE OVID (from 1980 to May 2011). Additional studies were identified through manual searches of key journals and the works of expert authors. Extraction of data informed an assessment of the level of evidence and risk of bias for each study using a predefined set of quality indicators. RESULTS A total of 394 abstracts were generated by the search but only nine studies met the inclusion criterion. Early sucking and swallowing problems were present in a consistent proportion of infants and were predictive of neurodevelopmental outcome in infancy in five of the six studies reviewed. LIMITATIONS The methodological quality of studies was variable in terms of research design, level of evidence (National Health and Medical Research Council levels II, III, and IV), populations studied, assessments used and the nature and timing of neurodevelopmental follow-up. CONCLUSIONS Based upon the results of this review, there is currently insufficient evidence to clearly determine the relation between early sucking and swallowing problems and neonatal brain injury. Although early sucking and swallowing problems may be related to later neurodevelopmental outcomes, further research is required to delineate their value in predicting later motor outcomes and to establish reliable measures of early sucking and swallowing function.
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Affiliation(s)
- Justine Slattery
- School of Human Communication Sciences, La Trobe University, Melbourne, Victoria, Australia.
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