Effect of fibrinolytic therapy on ST-elevation myocardial infarction clinical outcomes during the COVID-19 pandemic: A systematic review and meta-analysis

doi:10.4330/wjc.v15.i6.309

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World Journal of Cardiology

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World J Cardiol. Jun 26, 2023; 15(6): 309-323
Published online Jun 26, 2023. doi: 10.4330/wjc.v15.i6.309

Table 1 Characteristics of included studies

Ref.	Country	Study design/Sa	Study group/time period of study / sample size
Daoulah et al[15]	Saudi Arabia	Retrospective Cohort/500	Pandemic period STEMI/01/01/2020–30/04/2020/500
Daoulah et al[15]	Saudi Arabia	Retrospective Cohort/500	Pre-pandemic period STEMI/2018–2019/1285
Leng et al[16]	China	Retrospective Cohort	Pandemic period STEMI/23/01/2020–30/04/2020/164
Leng et al[16]	China	Retrospective Cohort	Pre-pandemic period STEMI/Equivalent period in 2019/240
Song et al[17]	China	Retrospective Cohort	Pandemic period STEMI/24/01/2020–31/03/2020/73
Song et al[17]	China	Retrospective Cohort	Pre-pandemic period STEMI/24/01/2019–31/03/2019/95
Wang et al[18]	China	Retrospective Cohort	Pandemic period STEMI/23/01/2020–20/03/2020/37
Wang et al[18]	China	Retrospective Cohort	Pre-pandemic period STEMI/01/09/2019–02/12/2019/41
Wu et al[19]	England	Retrospective Cohort	Pandemic period STEMI/01/01/2019/1600
Wu et al[19]	England	Retrospective Cohort	Pre-pandemic period STEMI/22/05/2020/15646
Xiang et al[20]	China	Retrospective Cohort	Pandemic period STEMI/20/02/2020/10516
Xiang et al[20]	China	Retrospective Cohort	Pre-pandemic period STEMI/27/12/2019/14634
Zhang et al[21]	China	Retrospective Cohort	Pandemic period STEMI/01/01/2020–31/03/2020/119
Zhang et al[21]	China	Retrospective Cohort	Pre-pandemic period STEMI/2018 and 2019/276
Huang et al[22]	China	Retrospective Cohort	Pandemic period STEMI/01/02/2020–15/04/2020/31
Huang et al[22]	China	Retrospective Cohort	Pre-pandemic period STEMI/01/01/2019–31/12/2019/31
Erol et al[23]	Turkey	Retrospective Cohort	Pandemic period STEMI/2020/485
Erol et al[23]	Turkey	Retrospective Cohort	Pre-pandemic period STEMI/2018/711
Mesnier et al[24]	France	Retrospective Cohort	Pandemic period STEMI/16/03/2020–12/02/2020/252
Mesnier et al[24]	France	Retrospective Cohort	Pre-pandemic period STEMI/17/02/2020–15/03/2020/331
Balghith[25]	Saudi Arabia	Retrospective Cohort	Pandemic period STEMI/01/2020–05/2020/81
Balghith[25]	Saudi Arabia	Retrospective Cohort	Pre-pandemic period STEMI/08/2019-12/2019/92
Clifford et al[26]	Canada	Retrospective Cohort	Pandemic period STEMI/17/03/2020–16/07/2020/193
Clifford et al[26]	Canada	Retrospective Cohort	Pre-pandemic period STEMI/15/11/2019–16/03/2020/238
Rodríguez-Leor et al[27]	Spain	Retrospective Cohort	Pandemic period STEMI/16/03/2020–14/04/2020/1009
Rodríguez-Leor et al[27]	Spain	Retrospective Cohort	Pre-pandemic period STEMI/01/04/2019–30/04/2019/1305
Calvão et al[28]	Portugal	Retrospective Cohort	Pandemic period STEMI/03/2020–04/2020/71
Calvão et al[28]	Portugal	Retrospective Cohort	Pre-pandemic period STEMI/03/2020–04/2020/80

STEMI: ST-elevation myocardial infarction.

Table 2 Baseline characteristics of the included subjects

Ref.	Study group	Age, years (SD)	Male, n (%)	Hypertension, n (%)	Diabetes mellitus, n (%)	Hyperlipidemia, n (%)	Smoking, n (%)
Daoulah et al[15]	Pandemic period STEMI	55.4 (11.8)	454 (90.8)	229 (46.7)	257 (52.1)	190 (38.9)	213 (43)
Daoulah et al[15]	Pre-pandemic period STEMI	56.5 (12.8)	1123 (87.5)	599 (47.6)	632 (50.4)	450 (35.8)	318 (41.6)
Leng et al[16]	Pandemic period STEMI	63.13 (13.6)	131 (79.9)	N/A	N/A	N/A	N/A
Leng et al[16]	Pre-pandemic period STEMI	62.21 (13.14)	178 (73.9)	N/A	N/A	N/A	N/A
Song et al[17]	Pandemic period STEMI	61.6 (13.1)	59 (80.82)	43 (58.9)	16 (21.9)	39 (53.4)	36 (49.3)
Song et al[17]	Pre-pandemic period STEMI	60.6 (13.9)	68 (71.57)	56 (59)	22 (23.2)	51 (53.7)	55 (57.9)
Wang et al[18]	Pandemic period STEMI	59.29 (11.46)	33 (89.18)	20 (54.05)	6 (16.21)	13 (35.13)	37 (100)
Wang et al[18]	Pre-pandemic period STEMI	55.49 (11.89)	35 (85.36)	18 (43.90)	5 (12.19)	15 (36.58)	31 (75.60)
Wu et al[19]	Pandemic period STEMI	65.1 (13.6)	1181 (73.81)	581 (36.31)	309 (19.31)	368 (23)	450 (28.12)
Wu et al[19]	Pre-pandemic period STEMI	65.76 (13.44)	11263 (71.98)	6060 (38.73)	3005 (19.20)	3645 (23.29)	4704 (30.06)
Xiang et al[20]	Pandemic period STEMI	61.59 (13.10)	7986 (75.94)	N/A	N/A	N/A	N/A
Xiang et al[20]	Pre-pandemic period STEMI	62.86 (12.33)	11019 (75.29)	N/A	N/A	N/A	N/A
Zhang et al[21]	Pandemic period STEMI	N/A	N/A	N/A	N/A	N/A	N/A
Zhang et al[21]	Pre-pandemic period STEMI	N/A	N/A	N/A	N/A	N/A	N/A
Huang et al[22]	Pandemic period STEMI	61	25 (80.6)	16 (51.6)	8 (25.8)	7 (22.6)	18 (58.1)
Huang et al[22]	Pre-pandemic period STEMI	60	25 (80.6)	18 (58.1)	6 (19.4)	8 (25.8)	20 (64.5)
Erol et al[23]	Pandemic period STEMI	59 (13)	552 (77.63)	221 (45.56)	151 (31.13)	108 (22.26)	248 (50.30)
Erol et al[23]	Pre-pandemic period STEMI	60 (14)	387 (79.79)	273 (38.39)	201 (28.27)	67 (9.4)	401 (56.39)
Mesnier et al[24]	Pandemic period STEMI	63.4 (12.5)	357 (74)	116 (24.11)	35 (7.27)	N/A	96 (19.95)
Mesnier et al[24]	Pre-pandemic period STEMI	64.4 (13.6)	509 (74)	139 (20.26)	55 (8.01)	N/A	131 (19.09)
Balghith[25]	Pandemic period STEMI	57.2 (12.6)	83 (90.21)	44 (54.32)	45 (48.91)	36 (39.13)	41 (44.56)
Balghith[25]	Pre-pandemic period STEMI	51.3 (11.5)	81 (100)	38 (41.3)	41 (44.56)	31 (33.69)	35 (38.04)
Clifford et al[26]	Pandemic period STEMI	65 (12)	169 (71)	99 (51.29)	55 (28.49)	86 (44.55)	53 (27.46)
Clifford et al[26]	Pre-pandemic period STEMI	64 (13)	135 (70)	123 (51.68)	54 (22.68)	99 (41.5)	93 (39.07)
Rodríguez-Leor et al[27]	Pandemic period STEMI	63.1 (12.5)	786 (78.4)	520 (51.9)	226 (22.6)	466 (46.7)	442 (44.6)
Rodríguez-Leor et al[27]	Pre-pandemic period STEMI	63.7 (13.2)	1023 (78.4)	647 (50)	224 (25.2)	592 (45.8)	581 (45.7)
Calvão et al[28]	Pandemic period STEMI	63.3 (12.7)	56 (78.9)	49 (69.01)	23 (32.39)	38 (53.52)	40 (56.33)
Calvão et al[28]	Pre-pandemic period STEMI	65.7 (12.8)	60 (75)	48 (60)	26 (32.5)	49 (57.5)	39 (48.75)

N/A: Not available; STEMI: ST-elevation myocardial infarction.

Citation: Khedr A, Hennawi HA, Khan MK, Elbanna M, Jama AB, Proskuriakova E, Mushtaq H, Mir M, Boike S, Rauf I, Eissa A, Urtecho M, Koritala T, Jain N, Goyal L, Surani S, Khan SA. Effect of fibrinolytic therapy on ST-elevation myocardial infarction clinical outcomes during the COVID-19 pandemic: A systematic review and meta-analysis. World J Cardiol 2023; 15(6): 309-323
URL: https://www.wjgnet.com/1949-8462/full/v15/i6/309.htm
DOI: https://dx.doi.org/10.4330/wjc.v15.i6.309