Bioinformatics prediction of potential mechanisms and biomarkers underlying dilated cardiomyopathy

Table 1 Top 10 differentially expressed genes in the dilated cardiomyopathy group vs normal group

Expression	Gene symbol	Description	logFC	adj. P value
	ASPN	Asporin	2.31	3.05E-22
	NPPA	Natriuretic peptide A	2.08	1.26E-11
	LUM	Lumican	1.87	4.56E-18
	MXRA5	Matrix remodeling associated 5	1.43	5.47E-14
UP	HBB	Hemoglobin subunit beta	1.20	3.08E-05
	COL1A2	Collagen type I alpha 2 chain	1.09	1.37E-10
	COL3A1	Collagen type III alpha 1 chain	1.05	2.39E-07
	OGN	Osteoglycin	1.01	5.38E-09
	FRZB	Frizzled related protein	0.99	1.08E-13
	EIF1AY	Eukaryotic translation initiation factor 1A Y-linked	0.96	1.33E-02
	MYOT	Myotilin	-1.89	1.70E-13
	ANKRD2	Ankyrin repeat domain 2	-1.44	3.00E-08
	PLA2G2A	Phospholipase A2 group IIA	-1.35	4.43E-07
	MYH6	Myosin heavy chain 6	-1.35	1.80E-05
	SERPINA3	Serpin family A member 3	-1.28	1.75E-18
Down	CYP4B1	Cytochrome P450 family 4 subfamily B member 1	-1.20	1.06E-07
	FCN3	Ficolin 3	-1.19	2.48E-13
	CNN1	Calponin 1	-1.16	2.09E-10
	PTX3	Pentraxin 3	-1.13	1.27E-04
	NRAP	Nebulin related anchoring protein	-1.11	1.30E-03

Table 2 Top 10 hub genes in the protein-protein interaction network

Gene symbol	Description	Rank	Degree
COL3A1	Collagen type III alpha 1 chain	1	18
COL1A2	Collagen type I alpha 2 chain	2	12
STAT3	Signal transducer and activator of transcription 3	3	11
CCL2	C-C motif chemokine ligand 2	3	11
FMOD	Fibromodulin	5	10
ASPN	Asporin	6	9
CXCL12	C-X-C motif chemokine ligand 12	6	9
LUM	Lumican	8	8
HSP90AA1	Heat shock protein 90 alpha family class A member 1	8	8
OGN	Osteoglycin	8	8