Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. May 26, 2022; 14(5): 282-296
Published online May 26, 2022. doi: 10.4330/wjc.v14.i5.282
Bioinformatics prediction of potential mechanisms and biomarkers underlying dilated cardiomyopathy
Zhou Liu, Ying-Nan Song, Kai-Yuan Chen, Wei-Long Gao, Hong-Jin Chen, Gui-You Liang
Zhou Liu, Gui-You Liang, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Zhou Liu, Ying-Nan Song, Kai-Yuan Chen, Wei-Long Gao, Hong-Jin Chen, Gui-You Liang, Translational Medicine Research Center, Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Ying-Nan Song, Hong-Jin Chen, Gui-You Liang, Department of Cardiovascular Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang 510000, Guizhou Province, China
Author contributions: Liu Z and Song YN designed this study; Chen KY collected the relevant data; Liu Z analyzed the data; Liu Z and Gao WL drafted the manuscript; Chen HJ and Liang GY reviewed and supervised this manuscript; All authors approved the final version of the article.
Supported by National Nature Science Foundation of China, No. 81960051, No. 8217021743, and No. 82160060; Project of High–Level Innovative Talents of Guizhou Province, No. [2016]4034; and Construction Funding from Characteristic Key Laboratory of Guizhou Province, No. [2021]313.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gui-You Liang, MD, Professor, School of Basic Medical Sciences, Guizhou Medical University, Dangwu, Guian District, Guiyang 550025, Guizhou Province, China. guiyou515@163.com
Received: December 14, 2021
Peer-review started: December 14, 2021
First decision: January 25, 2022
Revised: February 19, 2022
Accepted: April 26, 2022
Article in press: April 26, 2022
Published online: May 26, 2022
Processing time: 155 Days and 6.4 Hours
Core Tip

Core Tip: As the most common cause of heart failure, the diagnosis and therapy for dilated cardiomyopathy (DCM) are still unsatisfactory because of its indistinct pathogenesis and specific biomarkers. Thus, we comprehensively utilized the microarray data from the Gene Expression Omnibus database to uncover the biomarker and mechanisms underlying DCM development. Collagen type III alpha 1 chain and collagen type I alpha 2 chain, which are regulated by hsa-miR-5682 and hsa-miR-4500, may play critical roles in the pathogenesis of DCM through the acute inflammatory response and interleukin 17 signaling pathway. These biomarkers and mechanisms need to be further studied.