Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities

Table 1 Clinical trials

	Study details	Country	nIntervention		Main findings	Ref.
AA	Ascorbate previous to elective coronary angioplasty	Italy	28	28	Decrease in oxidative stress and improves reperfusion parameters	[74]
	Ascorbate previous to primary coronary angioplasty in patients with AMI	Chile	53	46	Improve ventricular function and reperfusion No differences in infarct size	[75]
NAC	N-acetylcysteine previous and after primary coronary angioplasty in patients with AMI	Germany	126	126	Decrease in oxidative stress No differences in infarct size	[105]
	N-acetylcysteine and nitroglycerine previous to primary coronary angioplasty in patients with AMI	Australia	67	65	Decrease in infarct size and cardiac damage biomarkers	[116]
DFO	Deferoxamine previous and after coronary angioplasty in patients with AMI	Australia	28	32	Decrease in oxidative stress No differences in infarct size	[114]

Main clinical studies that have used ascorbate, N-acetylcysteine or deferoxamine to prevent reperfusion injury in patients affected by acute myocardial infarction and treated with coronary angioplasty. AA: Ascorbate; NAC: N-acetylcysteine; DFO: Deferoxamine; IR: Ischemia reperfusion; AMI: Acute myocardial infarction.