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Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2018; 10(9): 74-86
Published online Sep 26, 2018. doi: 10.4330/wjc.v10.i9.74
Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities
Jaime González-Montero, Roberto Brito, Abraham IJ Gajardo, Ramón Rodrigo
Jaime González-Montero, Roberto Brito, Abraham IJ Gajardo, Ramón Rodrigo, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 70058, Chile
Roberto Brito, Abraham IJ Gajardo, Internal Medicine Department, University of Chile, Clinical Hospital, Santiago 70058, Chile
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Supported by FONDEF grant No. ID15I10285.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Ramón Rodrigo. Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Santiago 70058, Chile. rrodrigo@med.uchile.cl
Telephone: +56-2-29786126 Fax: +56-2-29786126
Received: March 27, 2018
Peer-review started: March 28, 2018
First decision: April 11, 2018
Revised: April 28, 2018
Accepted: May 9, 2018
Article in press: May 10, 2018
Published online: September 26, 2018
Processing time: 186 Days and 13.6 Hours
Core Tip

Core tip: Acute myocardial infarction is the leading cause of death in the world. At least half of the resulting myocardial damage is associated with myocardial reperfusion. Myocardial reperfusion injury is associated with reactive oxygen species production and iron mobilization. Treatment with antioxidants such as ascorbate, N-acetylcysteine, and an iron chelator such as deferoxamine, could prevent the development of this damage.