Exercise training in hypertension: Role of microRNAs

Figure 1 Effects of aerobic exercise training on the cardiac miRNAs in hypertension. CH: Cardiac hypertrophy; COL I: Collagen 1; COL III: Collagen 3; ACE: Angiotensin-converting enzyme; ACE2: Angiotensin-converting enzyme 2; THRAP-1: Thyroid hormone-associated protein 1; Purβ: Purine-rich element binding protein B; α-MHC: α-Myosin heavy chain; β-MHC: β-Myosin heavy chain.

Figure 2 Skeletal muscle miRNAs and selected target genes regulating cell proliferation, differentiation and hypertrophy/ atrophy by exercise training and cardiovascular diseases. The relationship between miRNAs and the mRNAs that encode proteins is shown. Insr: Insulin receptor; Irs1: Insulin receptor substrate 1; Pik3r1: Phosphatidylinositol 3-kinases regulatory 1; Purβ: Purine-rich element binding protein B; HDAC4: Histone deacetylase 4; IGF-1: Insulin-like growth factor 1; FGF: Fibroblast growth factor; SRF: Serum response factor; MAML1: Mastermind 1; PTEN: Phosphatase and tensin homolog; FoxO1: Forkhead box protein O1.