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World J Cardiol. Aug 26, 2014; 6(8): 713-727
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.713
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.713
Exercise training in hypertension: Role of microRNAs
Vander José das Neves, Tiago Fernandes, Fernanda Roberta Roque, Ursula Paula Renó Soci, Stéphano Freitas Soares Melo, Edilamar Menezes de Oliveira, Laboratory of Biochemistry and Molecular Biology of the Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, SP 05508-900, Brazil
Author contributions: Neves VJ, Fernandes T, Roque FR, Soci UP, Melo SFS wrote part of manuscript; Neves VJ was organizer; Oliveira EM, adviser, edited this manuscript.
Supported by Grants from Fundação de Amparo à Pesquisa do Estado de São Paulo-FAPESP, No. 2009/18370-3 and 2010/50048-1; by Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq, No. 476515/2012-2, USP/PRP-NAPmiR; by the grant from FAPESP, No. 2012/04104-2, No. 2013/10472-7 and No. 2010/09438-0; and by the grant from CNPq, No. 159827/2011-6, No. 159827/2011-6 and No. 308267/2013-3
Correspondence to: Edilamar Menezes de Oliveira, PhD, Laboratory of Biochemistry and Molecular Biology of the Exercise, School of Physical Education and Sport, University of São Paulo, Av. Professor Mello Moraes, 65, Cidade Universitária, São Paulo, SP 05508-900, Brazil. edilamar@usp.br
Telephone: +55-11-30912118 Fax: +55-11-38135921
Received: December 29, 2013
Revised: March 25, 2014
Accepted: May 29, 2014
Published online: August 26, 2014
Processing time: 262 Days and 9.1 Hours
Revised: March 25, 2014
Accepted: May 29, 2014
Published online: August 26, 2014
Processing time: 262 Days and 9.1 Hours
Core Tip
Core tip: Numerous studies have shown that exercise training exerts beneficial effects on hypertension. Thus, several important studies have established links between exercise training, hypertension and the post-transcriptional regulators known as miRNAs. It is interesting to note that exercise training helps to control hypertension through these regulators, by promoting changes in the cardiovascular system towards normality. This review summarizes the way in which exercise training acts on the cardiovascular system to control the side effects of hypertension on the heart, macro- and microcirculation, and skeletal muscles.