Differential effects of atrial and brain natriuretic peptides on human pulmonary artery: An in vitro study

Figure 1 Schematic representation of myograph setup for measuring isometric tension.

Figure 2 Cumulative concentration response curve to ANP and BNP (n = 15). Findings show that both ANP and BNP cause vasodilation. ANP is more potent and efficacious than BNP. pEC₅₀ of ANP and BNP were 8.96 ± 0.21 and 7.54 ± 0.18, respectively. ANP: Atrial natriuretic peptide; BNP: Brain natriuretic peptide.

Figure 3 Concentration response curve to ANP alone and ANP + BNP (n = 11). The E_max of ANP was 0.96 gf, which reduced to -0.675 gf when BNP was added. ANP: Atrial natriuretic peptide; BNP: Brain natriuretic peptide.