Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2019; 11(10): 236-243
Published online Oct 26, 2019. doi: 10.4330/wjc.v11.i10.236
Differential effects of atrial and brain natriuretic peptides on human pulmonary artery: An in vitro study
Azar Hussain, Robert T Bennett, Zaheer Tahir, Emmanuel Isaac, Mubarak A Chaudhry, Syed S Qadri, Mahmoud Loubani, Alyn H Morice
Azar Hussain, Robert T Bennett, Zaheer Tahir, Emmanuel Isaac, Mubarak A Chaudhry, Syed S Qadri, Mahmoud Loubani, Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham HU16 5JQ, United Kingdom
Alyn H Morice, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Castle Hill Hospital, Cottingham HU16 5JQ, United Kingdom
Author contributions: Hussain A was the principal investigator and was responsible for the design and conduct of the study; Hussain A was responsible for the acquisition, analysis and interpretation of the data and initial draft of the manuscript; Bennett RT, Tahir Z, Isaac E, Chaudhry MA, Qadri SS, Loubani M and Morice AH supervised the study and critically reviewed the article.
Institutional review board statement: The study was reviewed and approved by the North West – Liverpool Central Research Ethics Committee (Approval no: 15/NW/0808).
Informed consent statement: All patients were consulted and consented for resected lung tissue to be studied for our research prior to their operation at the time of their consent for surgery.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Azar Hussain, MBBS, MRCS (Ed), Clinical Research Fellow, Department of Cardiothoracic Surgery, Castle Hill Hospital, Castle Road, Cottingham HU16 5JQ, United Kingdom. azar.hussain@hey.nhs.uk
Telephone: +44-774-8019242
Received: February 10, 2019
Peer-review started: February 12, 2019
First decision: April 11, 2019
Revised: August 31, 2019
Accepted: September 15, 2019
Article in press: September 15, 2019
Published online: October 26, 2019
Processing time: 257 Days and 18.1 Hours
Core Tip

Core tip: This study demonstrated that both atrial natriuretic peptide and brain natriuretic peptide (BNP) vasodilate isolated human pulmonary artery rings, and that BNP acts as a partial agonist and inhibits the effects of atrial natriuretic peptide. The finding that the addition of BNP inhibits the effects of atrial natriuretic peptide suggests that BNP does act as a partial agonist, and could be advancing the progression to decompensated heart failure.