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World J Cardiol. Sep 26, 2017; 9(9): 731-736
Published online Sep 26, 2017. doi: 10.4330/wjc.v9.i9.731
Obesity paradox in patients undergoing coronary intervention: A review
Nirav Patel, Ossama Elsaid, Abhishek Shenoy, Abhishek Sharma, Samy I McFarlane
Nirav Patel, Ossama Elsaid, Department of Cardiology, Hartford Hospital, Hartford, CT 06001, United States
Abhishek Shenoy, University of Virginia Health System, SUNY Downstate, Brooklyn, NY 11203, United States
Abhishek Sharma, Department of Cardiology, SUNY Downstate, Brooklyn, NY 11203, United States
Samy I McFarlane, Department of Medicine, Division of Endocrinology, SUNY Downstate, Brooklyn, NY 11203, United States
Author contributions: Patel N made substantial contribution in conception, researching literature, designing and writing this manuscript; Shenoy A helped with writing and editing the content; Elsaid O helped with editing the content; Sharma A had important contribution in conception; McFarlane SI was moderator and participated revising it critically and advice to add important intellectual material in this manuscript.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nirav Patel, MD, Department of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06001, United States. nirav.patel@hhchealth.org
Telephone: +1-860-9726000 Fax: +1-860-6963224
Received: March 13, 2017
Peer-review started: March 14, 2017
First decision: April 20, 2017
Revised: May 8, 2017
Accepted: May 18, 2017
Article in press: May 19, 2017
Published online: September 26, 2017
Processing time: 195 Days and 14.7 Hours
Core Tip

Core tip: Literatures have shown strong association between obesity and coronary artery disease (CAD). However, a phenomenon known as obesity paradox (OX) exist which means that obese patients who undergo percutaneous coronary intervention for CAD, they have better outcome compared to normal and underweight patients. New studies also suggest racial and sexual disparities in OX. Multiple mechanisms and patho-physiology have been implicated for OX. In this review, we performed literature search of OX undergoing percutaneous intervention, propose mechanism of OX and racial and sexual disparities.