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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Does heart rate variability correlate with long-term prognosis in myocardial infarction patients treated by early revascularization?
Leonida Compostella, Li Van Stella Truong, Fabio Bellotto, Preventive Cardiology and Rehabilitation, Istituto Codivilla-Putti, I-32043 Cortina d’Ampezzo (BL), Italy
Leonida Compostella, Sabino Iliceto, Fabio Bellotto, Department Cardiac, Thoracic and Vascular Sciences, University of Padua, I-35100 Padova, Italy
Nenad Lakusic, Department Cardiology, Krapinske Toplice Hospital for Medical Rehabilitation, Gajeva 2, HR-49217 Krapinske Toplice, Croatia
Nenad Lakusic, Faculty of Medicine, J. J. Strossmayer University of Osijek, HR-31000 Osijek, Croatia
Caterina Compostella, Department Medicine, School of Emergency Medicine, University of Padua, I-35100 Padova, Italy
Author contributions: All authors contributed equally to this paper; each one of the above mentioned authors takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
Institutional review board statement: The study was approved by our Institutional Ethics Committee.
Informed consent statement: All participants had been fully informed on the procedures they were undergoing and a written consent was obtained from them.
Conflict-of-interest statement: No author has any conflict of interest to declare.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at: l.compostella@alice.it.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Leonida Compostella, MD, Preventive Cardiology and Rehabilitation, Istituto Codivilla-Putti, Via Codivilla, I-32043 Cortina d’Ampezzo (BL), Italy. l.compostella@alice.it
Telephone: +39-320-1722751 Fax: +39-0436-883379
Received: September 13, 2016
Peer-review started: September 14, 2016
First decision: October 21, 2016
Revised: November 2, 2016
Accepted: November 27, 2016
Article in press: November 29, 2016
Published online: January 26, 2017
Processing time: 126 Days and 22.5 Hours
Peer-review started: September 14, 2016
First decision: October 21, 2016
Revised: November 2, 2016
Accepted: November 27, 2016
Article in press: November 29, 2016
Published online: January 26, 2017
Processing time: 126 Days and 22.5 Hours
Core Tip
Core tip: Depressed heart rate variability (HRV) is usually considered a negative long-term prognostic factor after an acute myocardial infarction (MI). Anyway, most of the supporting research was conducted before the era of immediate reperfusion by percutaneous coronary intervention. In our study, in MI patients treated by early reperfusion abnormal values of HRV are present in a low percentage of cases. Low HRV does not correlate with long term-prognosis, both in ST-elevation and non-ST-elevation MI patients. Abnormal HRV seems to have lost prognostic significance in the present era of primary percutaneous revascularization.