Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Vitamin D and acute myocardial infarction
Valentina Milazzo, Monica De Metrio, Nicola Cosentino, Giancarlo Marenzi, Elena Tremoli, Centro Cardiologico Monzino, I.R.C.C.S., 20138 Milan, Italy
Author contributions: All the authors contributed to the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Giancarlo Marenzi, MD, Centro Cardiologico Monzino, I.R.C.C.S., Via Parea 4, 20138 Milan, Italy. giancarlo.marenzi@ccfm.it
Telephone: +39-02-580021 Fax: +39-02-58002287
Received: July 7, 2016
Peer-review started: July 10, 2016
First decision: September 12, 2016
Revised: November 16, 2016
Accepted: November 27, 2016
Article in press: November 29, 2016
Published online: January 26, 2017
Processing time: 194 Days and 22.3 Hours
Peer-review started: July 10, 2016
First decision: September 12, 2016
Revised: November 16, 2016
Accepted: November 27, 2016
Article in press: November 29, 2016
Published online: January 26, 2017
Processing time: 194 Days and 22.3 Hours
Core Tip
Core tip: Vitamin D deficiency is a prevalent condition and it is emerging as a new risk factor for coronary artery disease. Notably, hypovitaminosis D has been reported to be common in patients with acute myocardial infarction, and preliminary studies indicate a possible association with short-term and long-term morbidity and mortality. Although these observational initial proofs, interventional trials with supplementation of vitamin D have yielded controversial results. We herein discuss the current evidence suggesting an association between acute myocardial infarction and vitamin D deficiency, in terms of prevalence and prognostic impact, and the possible underlying mechanisms.