Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jun 26, 2016; 8(6): 368-374
Published online Jun 26, 2016. doi: 10.4330/wjc.v8.i6.368
Incidence and trends of cardiovascular mortality after common cancers in young adults: Analysis of surveillance, epidemiology and end-results program
Sadeer G Al-Kindi, Guilherme H Oliveira
Sadeer G Al-Kindi, Guilherme H Oliveira, Onco-Cardiology Center, University Hospitals Seidman Cancer Center and Harrington Heart and Vascular Institute, Cleveland, OH 44106, United States
Author contributions: Al-Kindi SG conceived the study, obtained the data, performed the statistical analysis, and drafted the manuscript; Oliveira GH conceived the study and revised the manuscript.
Institutional review board statement: This study included only deidentified data and was exempt from institutional review board approval at University Hospitals Case Medical Center.
Informed consent statement: This study used deidentified data and did not require informed consent.
Conflict-of-interest statement: Both authors have no conflict of interest pertinent to this study.
Data sharing statement: Data used for this analysis are available from SEER program (seer.cancer.gov).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guilherme H Oliveira, MD, FACC, Chief (Section of Heart Failure), Director (Onco-Cardiology Center), Director (Advanced Heart Failure and Transplantation Center, Harrington Heart and Vascular Institute and Seidman Cancer Center), Onco-Cardiology Center, University Hospitals Seidman Cancer Center and Harrington Heart and Vascular Institute, 11000 Euclid Avenue, Cleveland, OH 44106, United States. guilherme.oliveira@uhhospitals.org
Telephone: +1-216-8448242 Fax: +1-216-8448954
Received: February 27, 2016
Peer-review started: February 29, 2016
First decision: March 22, 2016
Revised: April 5, 2016
Accepted: April 21, 2016
Article in press: April 22, 2016
Published online: June 26, 2016
Processing time: 115 Days and 1.2 Hours
Core Tip

Core tip: Cancers and cardiovascular diseases share many risk factors. Premature cardiovascular mortality (CVM) has been described in cancer survivors. However, the trends of CVM in cancer survivors are largely unknown. Using a large national cancer registry in the United States, we show that CVM has decreased in survivors of breast and lung cancers, but not other cancers. Surprisingly, more than half of all cardiovascular deaths occur before age of 50 years. It is likely that interventions targeted at decreasing CVM in cancer survivors will decrease the overall mortality in those patients.