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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2016; 8(12): 728-734
Published online Dec 26, 2016. doi: 10.4330/wjc.v8.i12.728
Published online Dec 26, 2016. doi: 10.4330/wjc.v8.i12.728
Newer perspectives of coronary artery disease in young
Amitesh Aggarwal, M Velmurugan, Department of Medicine, University College of Medical Sciences and GTB Hospital, Delhi 110095, India
Saurabh Srivastava, Department of Medicine, School of Medical Sciences and Research, Sharda University, Noida 201308, India
Author contributions: All authors contributed to this paper.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amitesh Aggarwal, MD, Associate Professor, Department of Medicine, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110095, India. dramitesh@gmail.com
Telephone: +91-11-22586262
Received: June 29, 2016
Peer-review started: July 1, 2016
First decision: September 5, 2016
Revised: October 14, 2016
Accepted: November 1, 2016
Article in press: November 2, 2016
Published online: December 26, 2016
Processing time: 173 Days and 14.1 Hours
Peer-review started: July 1, 2016
First decision: September 5, 2016
Revised: October 14, 2016
Accepted: November 1, 2016
Article in press: November 2, 2016
Published online: December 26, 2016
Processing time: 173 Days and 14.1 Hours
Core Tip
Core tip: Coronary artery disease (CAD) in patients less than 45 years of age is termed young CAD. South Asians especially Indians are more vulnerable to have CAD in young age group. Although conventional risk factors, mainly smoking, are also important in young CAD but there are numerous other factors that are responsible for it. Several genes associated with lipoprotein metabolism are now found to be associated with young CAD. Gamma glutamyl transferase, vitamin D2 and osteocalcin seem to be associated with premature CAD in some studies. Angiographic studies shows predominance of single vessel disease in young CAD patients.