Lazzeri C, Valente S, Chiostri M, Gensini GF. Clinical significance of lactate in acute cardiac patients. World J Cardiol 2015; 7(8): 483-489 [PMID: 26322188 DOI: 10.4330/wjc.v7.i8.483]
Corresponding Author of This Article
Chiara Lazzeri, MD, Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy. lazzeric@libero.it
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Aug 26, 2015; 7(8): 483-489 Published online Aug 26, 2015. doi: 10.4330/wjc.v7.i8.483
Clinical significance of lactate in acute cardiac patients
Chiara Lazzeri, Serafina Valente, Marco Chiostri, Gian Franco Gensini
Chiara Lazzeri, Serafina Valente, Marco Chiostri, Gian Franco Gensini, Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy
Gian Franco Gensini, Department of Experimental and Clinical Medicine, University of Florence, AOU Careggi, Fondazione Don Carlo Gnocchi IRCCS, 50100 Florence, Italy
Author contributions: Lazzeri C and Gensini GF designed the study and wrote the manuscript; Valente S and Chiostri M critically revised the manuscript.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chiara Lazzeri, MD, Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy. lazzeric@libero.it
Telephone: +39-55-7947518 Fax: +39-55-7947518
Received: November 19, 2014 Peer-review started: November 20, 2014 First decision: December 12, 2014 Revised: April 6, 2015 Accepted: May 16, 2015 Article in press: May 18, 2015 Published online: August 26, 2015 Processing time: 280 Days and 17.9 Hours
Core Tip
Core tip: The present review is focused on the prognostic role of lactate levels in acute cardiac patients (acute coronary syndrome, cardiogenic shock, cardiac arrest). The prognostic impact of hyperlactatemia on mortality has been documented in cardiogenic shock and cardiac arrest even if there is no cut-off value of lactate to be associated with worse outcome or to guide resuscitation or hemodynamic management. Lactate clearance was reported to be clinically more reliable than lactate absolute value in these patients. Despite differences in study design, timing of lactate measurements and type of acute cardiac conditions (i.e., cardiogenic shock, cardiac arrest, refractory cardiac arrest), available evidence strongly suggests that higher lactate levels can be observed on admission in non-survivors and that a more favorable outcome is observed in patients with higher lactate clearance.
