Mavrogeni S, Markousis-Mavrogenis G, Papavasiliou A, Kolovou G. Cardiac involvement in Duchenne and Becker muscular dystrophy. World J Cardiol 2015; 7(7): 410-414 [PMID: 26225202 DOI: 10.4330/wjc.v7.i7.410]
Corresponding Author of This Article
Sophie Mavrogeni, MD, FESC, Cardiology Department, Onassis Cardiac Surgery Center, 50 Esperou Street, 175-61 P Faliro, 17674 Athens, Greece. soma13@otenet.gr
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Jul 26, 2015; 7(7): 410-414 Published online Jul 26, 2015. doi: 10.4330/wjc.v7.i7.410
Cardiac involvement in Duchenne and Becker muscular dystrophy
Sophie Mavrogeni, George Markousis-Mavrogenis, Antigoni Papavasiliou, Genovefa Kolovou
Sophie Mavrogeni, George Markousis-Mavrogenis, Genovefa Kolovou, Cardiology Department, Onassis Cardiac Surgery Center, 17674 Athens, Greece
Antigoni Papavasiliou, Department Pediatric Neurology, Pentelis Children Hospital, 15236 Athens, Greece
Author contributions: All the authors contributed to this manuscript.
Conflict-of-interest statement: The authors declear no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sophie Mavrogeni, MD, FESC, Cardiology Department, Onassis Cardiac Surgery Center, 50 Esperou Street, 175-61 P Faliro, 17674 Athens, Greece. soma13@otenet.gr
Telephone: +30-210-9882797 Fax: +30-210-9882797
Received: March 4, 2015 Peer-review started: March 4, 2015 First decision: March 20, 2015 Revised: April 14, 2015 Accepted: April 28, 2015 Article in press: April 30, 2015 Published online: July 26, 2015 Processing time: 152 Days and 22.6 Hours
Core Tip
Core tip: Duchenne and Becker muscular dystrophy are the commonest X-linked muscular diseases. Death is usually due to cardiac disease including ventricular dysfunction, heart block or malignant arrhythmias. Female carriers may also present cardiac involvement. Overt heart failure may be delayed or absent. Electrocardiography findings include conduction defects, arrhythmias and myocardial necrosis. Echocardiography assesses a marked variability of left ventricular dysfunction. Epicardial fibrosis in both patients and carriers has been documented by Cardiovascular Magnetic Resonance (CMR), even if overt muscular disease is absent. A combined approach using clinical and CMR assessment may motivate early cardioprotective treatment and delay serious cardiac complications.
