Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jun 26, 2015; 7(6): 344-350
Published online Jun 26, 2015. doi: 10.4330/wjc.v7.i6.344
Published online Jun 26, 2015. doi: 10.4330/wjc.v7.i6.344
Utility of electrophysiological studies to predict arrhythmic events
Gabriela Hilfiker, Paul Erne, Richard Kobza, Division of Cardiology, Luzerner Kantonsspital, 6000 Luzern, Switzerland
Andreas W Schoenenberger, Division of Geriatrics, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Paul Erne, Hirslanden Klinik St Anna, 6006 Luzern, Switzerland
Author contributions: The authors contributed equally to this work.
Ethics approval: This study was reviewed and approved by the Swiss Ethics Committees on research involving humans in Lucerne, Switzerland.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollement.
Conflict-of-interest: No conflict of interest.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Richard Kobza, MD, Division of Cardiology, Luzerner Kantonsspital, Spitalstrasse, Luzern 16, 6000 Luzern, Switzerland. richard.kobza@luks.ch
Telephone: +41-41-2055208 Fax: +41-41-2055109
Received: September 11, 2014
Peer-review started: September 11, 2014
First decision: September 28, 2014
Revised: February 12, 2015
Accepted: April 10, 2015
Article in press: April 14, 2015
Published online: June 26, 2015
Processing time: 287 Days and 12 Hours
Peer-review started: September 11, 2014
First decision: September 28, 2014
Revised: February 12, 2015
Accepted: April 10, 2015
Article in press: April 14, 2015
Published online: June 26, 2015
Processing time: 287 Days and 12 Hours
Core Tip
Core tip: In our long-term prospective cohort study we could reveal several important findings about the prognostic value of programmed ventricular stimulation for risk stratification of sudden cardiac death (SCD). First, in a mixed population with different cardiac pathologies inducible sustained ventricular tachyarrhythmia during electrophysiological stimulation (EPS) identified those at higher risk for SCD or appropriate implantable cardioverter defibrillators (ICD) activation. Second, left ventricular ejection fraction (LVEF) < 35% was another independent predictor of SCD surrogate. Third, in patients with LVEF > 35% negative EPS had a high negative predictive value for SCD and ICD activation.