Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Nov 26, 2015; 7(11): 707-718
Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.707
Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.707
Translational research of adult stem cell therapy
Gen Suzuki, Division of Cardiovascular Medicine, University at Buffalo, Clinical and Translational Research Center, Buffalo, NY 14203, United States
Author contributions: Suzuki G wrote the paper and performed data collection.
Supported by New York State NYSTEM foundation, No. N08G-433.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gen Suzuki, MD, PhD, Associate Professor of Medicine, Division of Cardiovascular Medicine, University at Buffalo, Clinical and Translational Research Center, 875 Ellicott Street, Buffalo, NY 14203, United States. gsuzuki@buffalo.edu
Telephone: +1-716-8292710 Fax: +1-716-8292665
Received: May 28, 2015
Peer-review started: June 1, 2015
First decision: August 4, 2015
Revised: August 20, 2015
Accepted: September 25, 2015
Article in press: September 28, 2015
Published online: November 26, 2015
Processing time: 186 Days and 2.2 Hours
Peer-review started: June 1, 2015
First decision: August 4, 2015
Revised: August 20, 2015
Accepted: September 25, 2015
Article in press: September 28, 2015
Published online: November 26, 2015
Processing time: 186 Days and 2.2 Hours
Core Tip
Core tip: Cell-based therapy emerged as a new approach to restore damaged heart function. Although cell therapy in experimental animal models is promising, beneficial effects in clinical trials are variable. This review summarizes recent preclinical and clinical applications on three specific adult stem cells (bone marrow derived mesenchymal stem cell, heart derived cardiosphere-derived cells and cardiac stem cell) and discuss about future approaches.