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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2015; 7(10): 652-657
Published online Oct 26, 2015. doi: 10.4330/wjc.v7.i10.652
Published online Oct 26, 2015. doi: 10.4330/wjc.v7.i10.652
Potential of dietary nitrate in angiogenesis
Christos Rammos, Peter Luedike, Ulrike Hendgen-Cotta, Tienush Rassaf, Department of Cardiology, Westgerman Heart and Vascular Center, University Hospital Essen, 45122 Essen, Germany
Author contributions: Rammos C and Luedike P contributed equally to this work, generated the figures and wrote the manuscript; Hendgen-Cotta U and Rassaf T contributed to the writing of the manuscript; Rammos C, Luedike P and Rassaf T designed the aim of the editorial and wrote the manuscript.
Supported by The DFG (Ra969/7-2) to Rassaf T.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tienush Rassaf, MD, Department of Cardiology, Westgerman Heart and Vascular Center, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany. tienush.rassaf@uk-essen.de
Telephone: +49-201-7234801 Fax: +49-201-7235618
Received: June 20, 2015
Peer-review started: June 27, 2015
First decision: July 27, 2015
Revised: August 12, 2015
Accepted: September 10, 2015
Article in press: September 16, 2015
Published online: October 26, 2015
Processing time: 135 Days and 13 Hours
Peer-review started: June 27, 2015
First decision: July 27, 2015
Revised: August 12, 2015
Accepted: September 10, 2015
Article in press: September 16, 2015
Published online: October 26, 2015
Processing time: 135 Days and 13 Hours
Core Tip
Core tip: Nitrate is a common constituent of our everyday diet and particularly high concentrations are found in leafy green vegetables such as spinach, lettuce, or beetroot. Evidence suggests that dietary nitrate supplementation increases the regenerative capacity of ischemic tissue and that this effect may offer an attractive nutrition-based strategy to improve ischemia-induced revascularization. We here summarize and discuss the regenerative capacity of dietary nitrate on the vascular system.