Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2015; 7(10): 645-651
Published online Oct 26, 2015. doi: 10.4330/wjc.v7.i10.645
Published online Oct 26, 2015. doi: 10.4330/wjc.v7.i10.645
Concepts of hypoxic NO signaling in remote ischemic preconditioning
Matthias Totzeck, Ulrike Hendgen-Cotta, Tienush Rassaf, Department of Cardiology, West German Heart and Vascular Center, University of Essen Medical School, 45157 Essen, Germany
Author contributions: Totzeck M, Hendgen-Cotta U and Rassaf T conceived, drafted and approved the manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Tienush Rassaf, MD, Professor, Department of Cardiology, West German Heart and Vascular Center, University of Essen Medical School, Hufelandstrasse 55, 45157 Essen, Germany. rassaf@gmx.de
Telephone: +49-201-7234801 Fax: +49-201-7235401
Received: May 29, 2015
Peer-review started: June 1, 2015
First decision: August 4, 2015
Revised: August 17, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: October 26, 2015
Processing time: 158 Days and 3.8 Hours
Peer-review started: June 1, 2015
First decision: August 4, 2015
Revised: August 17, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: October 26, 2015
Processing time: 158 Days and 3.8 Hours
Core Tip
Core tip: Therapeutic strategies to treat ischemia/reperfusion injury are urgently needed. Remote ischemic preconditioning (rIPC) appears to exert beneficial effects for patients. The underlying signaling remains incompletely understood. Following an outline of the existing evidence, we will characterize the existing knowledge and discuss future perspectives with particular emphasis on the interaction between the recently discovered hypoxic nitrite-nitric oxide signaling in rIPC.