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World J Cardiol. Aug 26, 2014; 6(8): 814-823
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.814
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.814
Renal sympathetic nervous system and the effects of denervation on renal arteries
Arun Kannan, Saravanan Balamuthusamy, Department of Medicine, University of Arizona, Tucson, AZ 85721, United States
Raul Ivan Medina, Saravanan Balamuthusamy, Vascular and Interventional Nephrology, Angiocare, Tucson, AZ 85721, United States
Nagapradeep Nagajothi, Cardiovascular Consultants, Canton, OH 44710, United States
Author contributions: Kannan A and Balamuthusamy S made substantial contributions to conception and design, acquisition of data; Kannan A, Medina RI and Nagajothi N contributed by drafting the article and revising it critically for important intellectual content; and Balamuthusamy S contributed to the final approval of the version to be published.
Correspondence to: Saravanan Balamuthusamy, MD, FASN, Assistant Professor, Director of Vascular and Interventional Nephrology, Angiocare, 224 W Exchange St, Tucson, AZ 85721, United States. sbalamuthusamy@email.arizona.edu
Telephone: +1-520-3276265 Fax: +1-520-3279300
Received: January 20, 2014
Revised: March 18, 2014
Accepted: June 10, 2014
Published online: August 26, 2014
Processing time: 240 Days and 10.3 Hours
Revised: March 18, 2014
Accepted: June 10, 2014
Published online: August 26, 2014
Processing time: 240 Days and 10.3 Hours
Core Tip
Core tip: Resistant Hypertension is a serious condition that could result in various comorbidities, if left untreated. The pathogenesis involves activation of sympathetic nervous system at the renal level and systemic level. Surgical therapy targeted at the systemic level has serious systemic side effects. Renal denervation offers an unique way of mitigating the chronic activation of sympathetic nervous system and controlling the high blood pressure.