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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Aug 26, 2014; 6(8): 791-801
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.791
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.791
Innate immune receptors in heart failure: Side effect or potential therapeutic target?
Katharina B Wagner, Stephan B Felix, Alexander Riad, Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany
Stephan B Felix, Alexander Riad, DZHK (German Centre for Cardiovascular Research), Partner site Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany
Author contributions: Wagner KB wrote the manuscript, literature research; Felix SB and Riad A edited and wrote the manuscript.
Correspondence to: Alexander Riad, MD, Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany. riad@uni-greifswald.de
Telephone: +49-3834-8680500 Fax: +49-3834-8680502
Received: January 15, 2014
Revised: April 18, 2014
Accepted: June 10, 2014
Published online: August 26, 2014
Processing time: 244 Days and 22.7 Hours
Revised: April 18, 2014
Accepted: June 10, 2014
Published online: August 26, 2014
Processing time: 244 Days and 22.7 Hours
Core Tip
Core tip: Heart failure (HF) is a leading cause of morbidity and mortality despite of current medical and interventional treatment. Activation of the innate immune system leading to or contribute to advanced HF is focus of intense and growing research. This review will focus on the role of innate immune receptors in HF. We will discuss the current knowledge about the correlation of innate immune activation and the clinical course in HF. In addition, we will comment on potential therapeutic implications of modulating the immune system in this syndrome.