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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Aug 26, 2014; 6(8): 782-790
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.782
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.782
Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy
Ludmila Rodrigues Pinto Ferreira, Amanda Farage Frade, Monique Andrade Baron, Isabela Cunha Navarro, Jorge Kalil, Edecio Cunha-Neto, Laboratory of Immunology, Heart Institute (InCor), School of Medicine, University of São Paulo, 05403-001 São Paulo, Brazil
Ludmila Rodrigues Pinto Ferreira, Amanda Farage Frade, Monique Andrade Baron, Isabela Cunha Navarro, Jorge Kalil, Edecio Cunha-Neto, Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, 05403-001 São Paulo, Brazil
Ludmila Rodrigues Pinto Ferreira, Amanda Farage Frade, Monique Andrade Baron, Isabela Cunha Navarro, Jorge Kalil, Edecio Cunha-Neto, Institute for Investigation in Immunology (iii), INCT, 05403-001 São Paulo, Brazil
Christophe Chevillard, Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385 Marseille, France
Author contributions: Ferreira LRP prepared the multiple drafts and wrote the manuscript; Chevillard C and Cunha-Neto E prepared the framework of the article; Frade AF, Baron MA and Navarro IC helped with scientific discussions; Kalil J, Chevillard C and Cunha-Neto E improved the quality of the draft.
Correspondence to: Edecio Cunha-Neto, MD, PhD, Researcher, Associate Professor of Medicine, Laboratory of Immunology, Heart Institute (InCor), School of Medicine, University of São Paulo. Av. Dr. Eneas de Carvalho Aguiar, 44 BL 2, 9° andar, 05403-001 São Paulo, Brazil. edecunha@usp.br
Telephone: +55-11-26615906 Fax: +55- 11-26615953
Received: December 29, 2013
Revised: March 29, 2014
Accepted: May 31, 2014
Published online: August 26, 2014
Processing time: 261 Days and 16.4 Hours
Revised: March 29, 2014
Accepted: May 31, 2014
Published online: August 26, 2014
Processing time: 261 Days and 16.4 Hours
Core Tip
Core tip: Chagas disease cardiomyopathy (CCC) occurs in 30% of those infected with the protozoan Trypanosoma cruzi, endemic in Latin America. It is an inflammatory cardiomyopathy with a worse prognosis than cardiomyopathies of other etiologies. Interferon (IFN)- γ is the main cytokine produced locally and induces strong signaling in cardiomyocytes. This review focuses on the pleiotropic protective and pathogenic effects of IFN-γ on CCC.