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World J Cardiol. Aug 26, 2014; 6(8): 706-712
Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.706
Transcatheter therapies for resistant hypertension: Clinical review
Adil Lokhandwala, Abhijeet Dhoble
Adil Lokhandwala, Department of Internal Medicine, University of Arizona College of Medicine at South Campus, Tucson, AZ 85713, United States
Abhijeet Dhoble, Department of Cardiology, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States
Author contributions: Lokhandwala A designed and wrote the manuscript, reviewed the manuscript and corrected the manuscript for its final presentation; Dhoble A reviewed the manuscript and corrected the manuscript for its final presentation.
Correspondence to: Abhijeet Dhoble, MBBS, MPH, FACP, Department of Cardiology, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room 2S03G-2, Los Angeles, CA 90048, United States. abhijeetdhoble@gmail.com
Telephone: +1-310-2486719 Fax: +1-310-4230127
Received: December 29, 2013
Revised: May 8, 2014
Accepted: May 29, 2014
Published online: August 26, 2014
Processing time: 261 Days and 19.2 Hours
Core Tip

Core tip: The aim of this paper is to review resistant hypertension (RHTN), including primary and secondary causes. Renal artery stenosis is one of the secondary cause of RHTN but angioplasty and stenting of renal artery for management of RHTN has failed to show any benefit. Sympathetic nervous system dysfunction is commonly noted in individuals with resistant hypertension. Renal sympathetic nerve denervation is a minimally invasive procedure which may help improve management of RHTN. However, the Symplicity HTN-3 trial failed to show a meaningful reduction in BP and has questioned this approach.