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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jul 26, 2014; 6(7): 610-620
Published online Jul 26, 2014. doi: 10.4330/wjc.v6.i7.610
Published online Jul 26, 2014. doi: 10.4330/wjc.v6.i7.610
Stem cell mechanisms during left ventricular remodeling post-myocardial infarction: Repair and regeneration
Rogelio Zamilpa, Mary M Navarro, Iris Flores, Sy Griffey, StemBioSys Inc., San Antonio, TX 78249, United States
Rogelio Zamilpa, Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States
Author contributions: Zamilpa R wrote the review; Navarro MM assisted with the tables, figures, revisions, and literature search; Flores I assisted with tables, figures, revisions, and literature search; Griffey S wrote review.
Correspondence to: Rogelio Zamilpa, PhD, StemBioSys Inc.,12500 Network Boulevard, Suite 105, San Antonio, TX 78249-3308, United States. zamilpa@uthscsa.edu
Telephone: +1-210-8779323 Fax: +1-210-8779323
Received: December 28, 2013
Revised: February 21, 2014
Accepted: May 14, 2014
Published online: July 26, 2014
Processing time: 235 Days and 10.9 Hours
Revised: February 21, 2014
Accepted: May 14, 2014
Published online: July 26, 2014
Processing time: 235 Days and 10.9 Hours
Core Tip
Core tip: Stem cell (SC)-based therapies hold promise to improve damaged myocardium repair and regeneration and thereby restore normal tissue function post-MI. In addition to the potential of SCs to regenerate myocardium, intrinsic properties of SCs such as their ability to home to areas of tissue damage make them an attractive tool for drug delivery. SCs, specifically mesenchymal stem cells, secrete multiple factors that can act in an autocrine and paracrine manner to regulate cell activation, recruitment, and survival during myocardium repair and regeneration.