Malfitano C, de Souza Junior AL, Irigoyen MC. Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors. World J Cardiol 2014; 6(6): 449-454 [PMID: 24976917 DOI: 10.4330/wjc.v6.i6.449]
Corresponding Author of This Article
Christiane Malfitano, PhD, Universidade Nove de Julho-Medicine Program, Rua Vergueiro 235/249-2° subsolo-Mestrado, 01504001 Sao Paulo, Brazil. chrismalfi@hotmail.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Cardiol. Jun 26, 2014; 6(6): 449-454 Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.449
Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors
Christiane Malfitano, Alcione Lescano de Souza Junior, Maria Cláudia Irigoyen
Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, Brazil
Christiane Malfitano, Universidade Nove de Julho-Medicine Program, 01504001 São Paulo, Brazil
Christiane Malfitano, Maria Cláudia Irigoyen, Instituto do Coração, Universidade de São Paulo, Faculdade de Medicina, 05403900 São Paulo, Brazil
Alcione Lescano de Souza Junior, Nursing Department, University of Mato-Grosso, 78200000 Mato Grosso, Brazil
Author contributions: All authors contributed to this paper.
Correspondence to: Christiane Malfitano, PhD, Universidade Nove de Julho-Medicine Program, Rua Vergueiro 235/249-2° subsolo-Mestrado, 01504001 Sao Paulo, Brazil. chrismalfi@hotmail.com
Telephone: +55-11-33859241 Fax: +55-11-33859241
Received: December 28, 2013 Revised: March 14, 2014 Accepted: April 17, 2014 Published online: June 26, 2014 Processing time: 179 Days and 16.6 Hours
Core Tip
Core tip: Hyperglycemia or diabetes triggers a conditioned state that may protect the heart against ischemic injury and associated detrimental effects. These beneficial effects are present in short term diabetes and/or moderate hyperglycemia. The increase in glucose availability, the preferred energy substrate of the heart in stress condition, is likely to be one of the main cardioprotector mechanisms of hyperglycemia. However, other cardioprotective mechanisms seem to be involved, such as the release of cellular survival factors, ions preventing overload and angiogenesis. A fuller understanding of the mechanisms underlying conditioned hyperglycemia is then critical for the development of effective therapeutic strategies against ischemic heart disease.
